摘要
目的:探讨丹地琼玉颗粒对干燥综合征(sj觟grensyndrome,SS)模型鼠的治疗作用。方法:用丹地琼玉颗粒低、中、高3种剂量对SS模型小鼠进行干预,并以生理盐水(NS)作为对照,观察丹地琼玉颗粒对SS模型鼠的唾液流量、CD4+T细胞、CD4+/CD8+及自身抗体的影响。结果:丹地琼玉颗粒能增加小鼠唾液流量,抑制Th细胞在唾液腺表达,促使自身抗体转阴。结论:丹地琼玉颗粒具有治疗SS小鼠的作用,其机制可能为抑制淋巴细胞对唾液腺的浸润。
Objective:To investigate the terapeutic efficacy and mechanism of Dan Di Qiong Yu Granule on sj o¨gren syndrome(SS)mice. Methods:Dan Di Qiong Yu Granule was administered in three different dose(low,middle and high) to female ICR mice, which had the similar clinical character of SS, using NS as contrast. After 6 weeks, the effect of Dan Di Qiong Yu Granule on SS mice was studied, such as their salivary flow, CD4+T cells, CD4+/CD8+, and their autologous antibodies. Results:Dan Di Qiong Yu Granule ould increase mice's salivary flow, constrain expression of Th cell on silvary glands, negate autologous antibodies. Conclusion:The therapeutic efficacy of Dan Di Qiong Yu Granule may be showed by decreasing lymphocytic infiltration on salivary gland.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2005年第4期266-267,272,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省中医药科研课题资助项目(苏中医政[2003]25号)
关键词
中药
丹地琼玉颗粒
干燥综合征
动物模型
唾液腺
traditional chinese medicine
Dan Di Qiong Yu Granule
sj o¨gren syndrome
animal model
salivary gland
