摘要
目的 :探讨急性颅脑损伤患者外周血TNF -α、IL -6、IL- 8和NO水平的变化及其临床意义。方法 :采用ELISA法检测TNF- α、IL- 6和IL -8,化学比色法检测NO。结果 :中、重型颅脑损伤患者外周血中TNF- α、IL- 6、IL -8和NO浓度明显高于对照组和轻型颅脑损伤患者 (P <0 . 0 1) ;轻型组颅脑损伤患者TNF- α高于对照组 ,但IL -6、IL- 8和NO浓度与对照组比较无显著意义。不同病情颅脑损伤患者外周血TNF α、IL- 6、IL -8和NO浓度与病情呈正相关。结论 :TNF- α、IL -6、IL- 8和NO参与了急性颅脑损伤的病理生理过程 ,其测定对于早期评估脑损伤的严重程度和预后有重要的临床意义。
Objective: To explore the changes of serum TNF-αIL-6IL-8 and NO levels in patients with acute brain injury and its clinical significance.Methods:The levels of cytokines were tested with ELISA method and the level of NO was tested with chromatometry.Results:The levels of TNF-αIL-6IL-8 and NO were significantly higher in patients with moderate and severe brain injury than those in normal volunteers and in patients with mild brain injury (P<0.01).The level of TNF-α in the patients with mild brain injury was higher than of that in the normal volunteers, but there were no difference of IL-6 IL-8 and NO between the mild brain injury patients and normal volunteers. The levels of the four pararheters were positively correlated to the patients condition (P<0.01).Conclusion:TNF-αIL-6IL-8 and NO were involved in the pathological process of brain injury. Determination of their contents was of clinical importance for evaluation of the severity of injury and outcome prediction.
出处
《河南医学研究》
CAS
2005年第1期55-57,共3页
Henan Medical Research
基金
湛江市科技攻关项目 (NO .ZK0 12 3 )
