摘要
目的 在高流量改良超滤时评估超滤时间对炎症因子的影响。方法 先天性心脏病患儿 40例,随机分成两组,对照组(C组)和实验组(L组)。记录患儿临床指标并测量肿瘤坏死因子和白介素 6的血清浓度。结果 40例患儿都顺利完成手术,术毕C组超滤时间(7. 83±0. 75)min, L组(14. 63±1. 06)min,C组滤出液量 (440. 00±91. 86)ml,L组为(766. 25±119. 85)ml。两组患儿临床指标没有显著差异,L组超滤前后炎症因子升高幅度明显低于C组, (P<0. 05)。结论 当延长超滤时间以增加滤液量可以降低炎症因子的上升幅度。
OBJECTIVE The objective of this study is to evaluate the effect of duration of high flow rate (up to 50ml/kg.min) modified ultrafiltion (MUF) on inflammatory mediators. METHODS 40 children were randomly divided into two groups, control group (C group) and study group (L group). At the beginning of MUF, the flow rate was about 10~15ml/(kg.min) and with the improvement of hemodynamic condition, it increased progressively to 40~50ml/kg.min. Clinical data were recorded and the concentrations of TNF and IL-6 were measured. RESULTS The operations were done uneventfully under moderate hypothermia cardiopulmonary bypass. The duration of high flow rate MUF was 7.83±0.75min in C group and 14.63±1.06min in L group. The ultrafiltrated volumes of C group and L group were 440.00±91.86ml, 766.25±119.85ml respectively. In C group, the TNF increased from 1.29±0.38ug/ml to 1.76±0.41 and IL-6 from 143.28±30.16ug/ml to 199.24±51.97ug/ml during MUF while in L group, TNF from 1.44±0.34ug/ml to 1.61±0.30ug/ml and IL-6 from 153.51±38.49 to 162.41±27.85ug/ml. It showed that at the end of MUF, the inflammatory mediators were lower in L group (P<0.05), however, there are no significant clinical differences. CONCLUSION Increasing the ultrafiltrated volume by prolonging the duration of high flow rate MUF can decrease the accumulation of inflammatory mediators.
出处
《中国体外循环杂志》
2005年第1期4-6,9,共4页
Chinese Journal of Extracorporeal Circulation
