摘要
目的 探讨Graves病与碘的关系 ,以提高该病的治愈率和降低发病率。方法 采用砷铈催化分光光度计法对 40 9例Graves(GD)病者和 410例正常对照者的尿碘测定。结果 GD患病组尿碘含量均值 ( 14 1.16± 92 .79) μg L ,正常对照组尿碘含量均值 ( 2 0 2 .2± 3 9.48) μg L ,两者比较有显著性差异 ( P <0 .0 1) ;患病组有 2 64例尿碘含量 <10 0 μg L ,均值 ( 82 .74± 14 .71) μg L占 64 .5 5 %,97例尿碘含量在 ( 10 0～ 2 99) μg L ,均值 ( 2 0 1.5± 5 1.71) μg L ,占 2 3 .72 %与正常对照组比较无差异性 (P >0 .0 5 ) ;48例尿碘含量 >3 0 0 μg L ,均值 ( 3 40 .5 1± 2 8.77) μg L ,11.79%与正常对照组比较有显著性差异 (P <0 .0 1)。结论 本地区存在高碘、低碘和高、低碘以外相关因素Graves病 ,但仍以缺碘为主要因素 ,其次为高、低碘以外、高碘。女性患者多于男性 ,占 90 .95 %,两者尿碘水平无差异性。
Objective To explore the relations between Graves disease (GD)and iodine so as to raise the cure rate and lower the morbidity.Methods Urinary iodine determination on 409 Graves disease(GD)patients and 410 healthy persons with method for determination of urine iodine by As-Ce catalytic spectrophotometery.Results The average content value of the GD patient group detected is 141.16±92.97 μg/L while that of the control group is 202.2±39.48 μg/L,there exists a significant difference(P<0.01);of the urinary iodine contents of the GD patient group 264 were less than 100 μg/L with an average value of 82.74±14.71 μg/L taking 64.55% and 97 ranged from 100 to 299 μg/L with an average value of 201.5±51.71 μg/L which showed no difference comparing with those of the control group(P>0.05).Conclusions There exists Graves disease caused by high iodine,low iodine and other factors unrelated to low and high iodine in this area,mainly by iodine deficiency followed by other factors unrelated to low and high iodine.Female patients are more than male patients,constituting 90.95% of the total while no signitficant difference of urinary iodine contents is found.In the low iodine group,patients from the rural area take a high proportion.
出处
《中国地方病防治》
2004年第2期117-119,共3页
Chinese Journal of Control of Endemic Diseases
基金
右江民族医学院科研经费资助课题 (2 0 0 1 )
