摘要
自江苏海门产百合科植物玉竹［Ｐｏｌｙｇｏｎａｔｕｍｏｄｏｒａｔｕｍ（Ｍｉｌｌ．）Ｄｒｕｃｅ］根茎的乙醇提取物中分得六个单体化合物，根据化学性质和光谱解析，鉴定其化学结构分别为β－谷甾醇（Ｓ－Ａ）），β－谷甾醇－３－Ｏ－β－Ｄ－吡喃葡萄糖甙（Ｓ－Ｂ），２５（Ｒ，Ｓ）螺甾－５－烯－３β－醇－３－Ｏ－β－Ｄ－吡喃葡萄糖基－（１→２）－［β－Ｄ－吡喃木糖基－（１→３）］－β－Ｄ－吡喃葡萄糖基（１→４）－β－吡喃半乳糖甙（ＰＯＤ－Ｉ），２５（Ｒ）螺甾－５－烯－３β，１４ａ－二醇－３－０－β－Ｄ－吡喃葡萄糖基－（１→２）－［β－Ｄ－吡喃木糖基－（１→３）］－β－Ｄ－吡喃葡萄糖基－（１→４）－β－Ｄ－吡喃半乳糖甙（ＰＯＤ－ＩＩ），２５（Ｒ，Ｓ）螺甾－５－烯－３β，１４ａ－二醇－３－Ｏ－β－Ｄ－吡喃葡萄糖基－（１→２）－［β－Ｄ－吡喃葡萄糖基－（１→３）］－β－Ｄ－吡喃葡萄糖基（１→４）－β－Ｄ－吡喃半乳糖甙（ＰＯＤ－ＩＩＩ）和２５（Ｒ，Ｓ）螺甾－５－烯－３β－醇－３－Ｏ－β－Ｄ－吡喃葡萄糖基－（１－２）－［β－Ｄ－吡喃葡萄糖基－（１→３）］－β－Ｄ－吡喃哺葡萄糖基（１→４）－β－Ｄ－吡喃半乳糖甙（ＰＯＤ－ＩＶ）。ＰＯＤ－?
From the ethanol extract of the Chinese traditional
medicine ,rhizomes of Polygona-tum odoratum,a new steroidal saponin
POD-Ⅱ together with β-sitosterol and its glucoside ,and threeknown
saponins were isolated.On the basis of chemical evidence and spectral
analysis(UV ,IR,EI-MS,1 HNMR and1 3CNMR),the structure of POD-Ⅱ was
elucidated as 3- O-β-D-glucopyranosyL-(1→2)- [β-D- xylopyranosyl-(
1→3)]- β-D- glucopyranosyl-(1→4)-galactopyranosyl-25(R)-
spirost-5- en-3β,14α-diol.Preliminary pharmacologicaI tests showed
that POD-Ⅱ could induce the colony stimu-lating factor(CSF)in mouse
serum; and POD-Ⅲ,at the concentration of 0.1μg·ml-1 was shown
tosynergize the suboptimal and optimal concentration of Con A and
lipopolysaccharide to stimulate lymp-hocytes proliferation.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第3期215-222,共8页
Acta Pharmaceutica Sinica
关键词
玉竹
甾体皂甙
化学成分
Polygonatum odoratum(Mill.)Druce
Steroidal saponin:Colony stimulating
factor(CSF)
Lymphocytes proliferation
