摘要
６β－乙酰氧基去甲托烷（６β－ａｃｅｔｏｘｙｎｏｒｔｒｏｐａｎｅ，６β－ＡＮ）是一种新型Ｍ２受体激动剂，兔１０ｕｇ·ｋｇ－１ｉｖ，犬２，５，２０ｕｇ·ｋｇ－１ｉｖ均导致呼吸频率、潮气量、每分通气量明显减少（Ｐ＜０．０５或０．０１），呈剂量依赖关系。ｐＯ２降低，ｐＣＯ２升高。较小剂量给兔０．５，１．０，２．０，４．０ｕｇ·ｋｇ－１ｉｖａ和犬０．２５，０．５，１．０ｕｇ·ｋｇ－１ｉｖａ亦产生与静脉给药相似的呼吸抑制效应。ＡＦ－ＤＸ１１６能拮抗６β－ＡＮ的呼吸抑制作用，ＰＺ则与６β－ＡＮ产生协同作用。表明６β－ＡＮ有呼吸抑制作用，并可能与其激动呼吸中枢Ｍ２受体有关。
β-AN(6β-acetoxy nortropane),a novel
selective M2-receptor agonist,causeddecrease in FR,TV,MVV and pO2 and
increase of pCO2 when intravenous injection of 10 ug·kg-1in
conscious rabbits or 2,5, 20 ug·kg-1 in conscious dogs was given(P<.
05 or 0.01).Theinhibitory effect on MVV exhibited a dose-dependent
relationship.Small doses of 6β-AN icv(0.5,1,2,4 ug·kg-1 in the
conscious rabbits)and iva(6.25,0.5 and 1.0 ug·kg-1 in anesthetized
dogs)decreased FR,TV,MVV and pO2 and increased pCO2 as well.These
results were reversed after admi-nistration of AF-DX116 and enhanced
after administration of pirenzepine.Thus,it appears that
theinhibitory action of 6β-AN on respiration might be related to
stimulation of the inhibitory M2cholinergic receptor in respiratory
center.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第7期497-501,共5页
Acta Pharmaceutica Sinica
关键词
乙酰氧基
去甲托烷
受体
呼吸中枢
M2 cholinergic receptor
6β-Acetoxy
nortropane
Respiratory center
