摘要
目的:制备复方硫糖铝分散片并对其质量进行评价。方法:采用均匀设计筛选处方,粉末直接压片制备复方硫糖铝分散片。测定它的崩解度、溶出度和混悬性,与胶囊剂比较,并考察分散片的稳定性。结果:制备的复方硫糖铝分散片的各项性能优于胶囊,分散片和胶囊剂的崩解时间分别为(1±0.12)和(20±3.93)min;分散片中的硫糖铝和叶酸在5min时即有约75%和85%溶出,而此时胶囊剂中两成分的溶出均<10%。结论:复方硫糖铝分散片质量稳定,适合临床应用。
Objective: To prepare the dispersible tablets of compound sucralfate and evaluate their quality. Methods: The formulation was screened by means of uniform design and the tablets were prepared by press the powder directly. Their disintegration, dissolution and suspension were determined and compared with those of the capsules. The stability of the dispersible tablets was investigated. Results: The performance of the prepared dispersible tablets was better than that of the capsules. The disintegration time of dispersible tablets and capsules was (1±0. 12) mm and (20±3. 93) mm, respectively. The dissolution rates of sucralfate and folic acid in dispersible tablets were 75% and 85% respectively in 5 mm, while those in capsules were all <10% in the same time. Conclusion: The dispersible tablets of compound sucralfate are stable in quality and are suitable for clinical application.
出处
《药学服务与研究》
CAS
CSCD
2005年第1期51-53,共3页
Pharmaceutical Care and Research
关键词
硫糖铝
叶酸
分散片
sucralfate
folic acid
dispersible tablet
