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药物靶标研究中的功能基因组学 被引量：5

Functional genomics in drug target research
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摘要 在人类基因组计划完成以及新的生物技术推动下,传统的药物发现模式正在向基因组学为基础的现代药物发现模式转变。药物靶标的发现,是药物发现途径中最关键的一个环节。该文就目前靶标不同阶段的研究策略和方法做一综述,重点介绍新的生物技术对药物靶标研究所产生的影响并展望未来发展趋势。 Due to the completion of human genome project and the advent of new technologies, the traditional drug discovery is shifting to genomics-based drug discovery. Target discovery is an important first step in drug discovery pipeline. In this review, we critically introduce the strategies and biology technologies for target discovery, especially focus on the likely impact of new technologies in drug target research and speculate the future trend of target research.
作者 王玉 汪海
机构地区 军事医学科学院毒物药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2005年第3期266-268,共3页 Chinese Pharmacological Bulletin
基金 国家"863"计划重大专项基金资助项目(No2002AA2Z3137)
关键词 药物发现模式 生物技术 药物靶标 drug discovery biology technologies drug target
分类号 R-05 [医药卫生] R394 [医药卫生—医学遗传学]
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参考文献16

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二级参考文献25

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中国药理学通报
2005年 第3期

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