摘要
目的:探讨中药抗敏剂治疗牙本质过敏症的疗效及作用机制。方法:将中药抗敏剂制备成漱口剂、涂擦剂和糊剂 3种剂型,分组进行临床应用,与对照组进行对比,观察各组治疗后即刻、3个月及半年的临床疗效。通过扫描电镜观察中药抗敏剂对牙本质小管的作用。结果:糊剂联合载药牙列托盘治疗牙本质过敏症与漱口剂、涂擦剂和对照组对比有显著统计学差异(P<0. 05)。扫描电镜观察中药抗敏剂作用后,牙本质小管开口基本消失。结论:中药抗敏剂可有效堵塞牙本质小管,治疗牙本质过敏症,联合载药牙列托盘疗效更为持久。
Objective:To investigate the effect of self-made herbal desensitizer in the treatment of dentine hypersensitivity. Methods:Herbal desensitizer was made of corydalis tuber, asarum herb, long pepper, galangal rhizom and prepared wild aconite root into three different forms:gargle(GG), embrocation(EC) and cataplasm(CP). 750 g/L sodium fluoride paste(SFP) was used as the control. 765 teeth with dentine hypersensitivity in 216 patients were treated with GG,CP,EC and SFP respectively at random. In group CP dental tray was used to carry the desensitizer.The clinical effects were observed in the following 6 months. The effects of the drugs on the obstruction of detinal tubules were observed with scanning electron micoscope(SEM) in the in vitro experiment on 12 extracted teeth.Results:The clinical immediate effective rate(%)of GG,CP,EC and SFP was 57.3(110/192),91.8(179/195),86.9(166/191) and 63.6(119/187) (CP vs GG,EC or SFP P<0.01),3-month effective rate 47.8(88/184),92.3(168/182), 82.0(155/189) and 54.5(96/176) (CP vs GG or SFP P<0.01, CP vs EC P<0.05),6-month effective rate 47.5(77/162),89.9(152/169),82.5(146/177) and 49.1(78/159) (CP vs GG,EC or SFP P<0.01),respectively. In vitro experiment showed that CP was the most effective in blocking the opening of dentinal tubules among the tested agents.Conclusions:The self-made herbal desensitizer is effective and CP is the most effective in the treatment of dentinal hypersensitivity.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2005年第2期262-265,共4页
Journal of Practical Stomatology
关键词
中药抗敏剂
牙本质过敏症
扫描电镜
Self-made herbal desensitizer
Dentine hypersensitivity
Scanning electron microscopic (SEM)
