A Convenient Method for the Asymmetric Synthesis of KAD-1229 被引量：2

A Convenient Method for the Asymmetric Synthesis of KAD-1229

下载PDF

导出

摘要 A new method for preparation of the potent hypoglycemic KAD-1229 was developed. The key step of this method is diasteroselective alkylation in high optical purity and good yield by using easily available Oppolzer’s camphor sultam as chiral auxiliary. A new method for preparation of the potent hypoglycemic KAD-1229 was developed. The key step of this method is diasteroselective alkylation in high optical purity and good yield by using easily available Oppolzer’s camphor sultam as chiral auxiliary.

作者 JianChaoLIU YuSheYANG RuYunJI

机构地区 StateKeyLaboratoryofDrugResearch

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第4期430-432,共3页 中国化学快报（英文版）

关键词 KAD-1229 MITIGLINIDE camphorsultam. KAD-1229, mitiglinide, camphorsultam.

分类号 R977.15 [医药卫生—药品] R587.3 [医药卫生—内分泌]

引文网络
相关文献

参考文献14

1H. Ohnota, T. Koizumi, N. Tsutsumi, et al., Pharmacol. Exp. Ther., 1994, 269, 489.
2H.Ohnota, M. Kobayashi, T. Kiozumi, et al., Biochem. Pharmacol., 1995, 49, 165.
3M.Kinukawa, H. Ohnota, T. Azisawa, Br. J. Pharmacol., 1996, 117, 17021.
4T. Yamaguchi, T. Yanagi, H. Hokari, et al., Chem. Pharm. Bull., 1997, 45, 1518
5T.Yamaguchi, T. Yanagi, H. Hokari, et al., Chem. Pharm. Bull., 1998, 46, 337.
6D.A. Evans, M. D. Ennis, D. J. Mathre, J. Am. Chem. Soc., 1982, 104, 1737.
7J.P. Lecouve, C. Fugier, J. C. Souvie, WO pat. 9901430, 2000.
8M. Vandewalle, J. Van der Eycken, W. Oppolzer, et al., Tetrahedron, 1986, 42, 4035
9F. A.Davis, J. C. Towson, M. C. Weismiller, et al., J. Am. Chem. Soc., 1988, 110, 8477.
10D. Brundish, A. Bull, V. Donovan, et al., J. Med. Chem., 1999, 42, 4584.

同被引文献13

1JiaChengNING ShuMAO YeDiGUAN.Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries[J].Chinese Chemical Letters,2005,16(1):17-19. 被引量：1
2Ye WANG Zhan Zhu LIU Ye Feng TANG Shi Zhi CHEN.An Efficient Synthetic Strategy for Construction of Functionalized Pentacyclic Skeleton of ecteinascidin-saframycin Alkaloids[J].Chinese Chemical Letters,2006,17(7):853-856. 被引量：1
3Xue Song Chen Shi Jun Da Li Hong Yang Bo Yan Xu Ztfi Xiang Xie Ying Li.A new convenient asymmetric approach to herbarumin Ⅲ[J].Chinese Chemical Letters,2007,18(3):255-257. 被引量：1
4Ji-Shu Zhang,Cui-Fen Lu,Zu-Xing Chen,Yan Li,Gui-Chun Yang.Boron enolates of a hydantoin chiral auxiliary derived from l -phenylalanine: a versatile tool for asymmetric aldol reactions[J].Tetrahedron: Asymmetry.2012(1)
5Gopal Khatik,Ravi Khurana,Varun Kumar,Vipin Nair.Asymmetric Induction by (S)-4-Isopropyl-1-phenylimidazolidin-2-thionein Titanium-Mediated Aldol Reactions and Its Application in Enantioselective Synthesisof (R)-Baclofen[J].Synthesis.2011(19)
6Fabien Fécourt,Gérald Lopez,Arie Van Der Lee,Jean Martinez,Georges Dewynter.Cyclosulfamide as a chiral auxiliary: application to efficient asymmetric synthesis (alkylation/aldolization)[J].Tetrahedron: Asymmetry.2010(19)
7Jesús M. García,José M. Odriozola,Ainara Lecumberri,Jesús Razkin,Alberto González.A concise and efficient route to the Alzheimer’s therapeutic agent ( R )-arundic acid[J].Tetrahedron.2008(47)
8Tomoya Kotake,Yoshio Hayashi,S. Rajesh,Yoshie Mukai,Yuka Takiguchi,Tooru Kimura,Yoshiaki Kiso.Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions[J].Tetrahedron.2005(15)
9Gue-Jae Lee,Taek Hyeon Kim,Jae Nyoung Kim,Uk Lee.l -Valinol and l -phenylalaninol-derived 2-phenylamino-2-oxazolines as chiral auxiliaries in asymmetric alkylations[J].Tetrahedron: Asymmetry.2002(1)
10Claudio Palomo,Mikel Oiarbide,Alberto Gonaz’alez,Jesús M. García,Fabienne Berrée.Exo , exo -2,3-Diaminoborneol-derived imidazolidinone as chiral auxiliary for asymmetric alkylations[J].Tetrahedron Letters.1996(26)

引证文献2

1Long-Duo Zhang,Cui-Fen Lu,Zu-Xing Chen,Gui-Chun Yang,Jun-Qi Nie.Diastereoselective alkylation reactions employing a new camphor-based 2-phenylimino-2-oxazolidine chiral auxiliary[J].Chinese Chemical Letters,2014,25(11):1466-1468.
2Rong-Guo Ren,Jing-Yi Ma,Zhuo-Ya Mao,Yi-Wen Liu,Bang-Guo Wei.Asymmetric synthesis of emericellamide B[J].Chinese Chemical Letters,2015,26(10):1209-1215.

1潘满根,刘克良,仲伯华.那格列奈及其类似物的研究进展[J].中国新药杂志,2002,11(8):585-587. 被引量：6
2卜云涛,边波,万征.非对称性二甲基精氨酸和冠状动脉性心脏病及其危险因素的关系[J].中国循证心血管医学杂志,2011,3(1):63-66. 被引量：8
3张淑蓉,李雷雷,文军,梁国娟.依折麦布的酶法合成[J].西南师范大学学报（自然科学版）,2015,40(10):173-176. 被引量：1
4衡先培,杨柳清,翁苓.格列奈类降糖药的临床应用[J].中国乡村医药,2006,13(10):34-36. 被引量：2
5李宗芳,韩庆,吴涛,刘效恭,李宏波,杨晓婷.A NEW METHOD OF PRODUCING PORTAL HYPERTENSION IN DOGS[J].Journal of Pharmaceutical Analysis,1998,12(1):74-77.
6胡锐,李宝莉,刘继平,张晓双,袁秉祥.西布曲明对hERG钾电流的抑制作用[J].西安交通大学学报（医学版）,2009,30(4):442-444.
7朱理业,王振海,王东峰,王华,万俊峰,李浩.阜阳地区1991～1994年EHF监测报告[J].安徽预防医学杂志,1996,2(3):22-24. 被引量：2
8解素花,闫阅.高效液相色谱法测定脂质体制剂中醋酸氯己定的含量[J].药物分析杂志,2006,26(2):263-264. 被引量：3
9周荣,孟庆华,梁炽森,张楚瑜.Direct　sequencing　of　hepatitis　C　virus　cDNA　using　the　product　of　single　primer　polymerase　chain　reaction[J].Journal of Medical Colleges of PLA(China),1994,9(4):313-315.
10王洪巨,刘俊,史晓俊,张恒,高大胜,包宗明,蔡鑫.血浆非对称二甲基精氨酸浓度与冠状动脉粥样硬化程度有关[J].岭南心血管病杂志,2007,13(5):327-329. 被引量：2

Chinese Chemical Letters

2005年第4期

浏览历史

内容加载中请稍等...

A Convenient Method for the Asymmetric Synthesis of KAD-1229 被引量：2

参考文献14

同被引文献13

引证文献2

相关作者

相关机构

相关主题

浏览历史