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成人隐匿性自身免疫糖尿病的治疗 被引量：1

Treatment of latent autoimmune diabetes in adults
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摘要 成人隐匿性自身免疫糖尿病(Latent autoimmune diabetes in adults,LADA)是成年起病的1型糖尿病的一种重要亚型.早在1977年,Irvine等观察到2型糖尿病中胰岛细胞抗体(ICA)阳性者多无肥胖、血浆C肽水平低、易出现继发口服降糖药失效、较多伴有自身免疫病.1987年,Kobayashi[1]建议称此类患者为缓慢进展性胰岛素依赖型糖尿病(SPIDDM).在谷氨酸脱羧酶抗体(GAD-Ab)被鉴定为胰岛自身抗体后,1993年Tuomi等[2] 检测并发现了一组成年发病的非胰岛素依赖性糖尿病(NIDDM)患者GAD-Ab阳性,并将其命名为LADA.LADA患者的特点[3]为:①疾病的性质属于自身免疫性,为1型糖尿病;②起病晚,成年出现;③起病方式缓慢,有较长阶段(至少半年)呈非胰岛素依赖状态.1999年,WHO正式定义其为1型糖尿病的亚型.LADA以胰岛β细胞自身免疫损伤为特征,其进展速度不一,β细胞可长期维持一定的功能,也可较快进展为胰岛素依赖.现主张尽早从貌似2型糖尿病(TZDM)中鉴别出LADA并早期治疗,以减轻胰岛自身免疫损害,保护胰岛β细胞功能,从而延缓胰岛素依赖阶段的出现和糖尿病急、慢性并发症的发生.
作者 周智广 熊斌
机构地区 中南大学湘雅二医院内分泌科
出处 《实用药物与临床》 CAS 2005年第2期1-2,共2页 Practical Pharmacy and Clinical Remedies
关键词 成人隐匿性自身免疫糖尿病 治疗 胰岛细胞抗体 血浆C肽 自身免疫病
分类号 R587.1 [医药卫生—内分泌]
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参考文献22

  • 1欧阳玲莉,周智广,彭健,伍汉文.雷公藤多甙治疗LADA的初步临床观察[J].中国糖尿病杂志,2000,8(1):7-9. 被引量：40
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二级参考文献28

  • 1王建民,周智广,文建新,伍汉文,ThomasDyrberg.谷氨酸脱羧酶(GAD_(65))自身抗体的放射配体检测法[J].中国糖尿病杂志,1997,5(2):85-88. 被引量：21
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