摘要
目的:比较西酞普兰与阿米替林治疗阿尔茨海默病(AD)所致抑郁的患者临床疗效和安全性。 方法:80例诊断为AD的抑郁患者,随机分成两组,分别用西酞普兰和阿米替林治疗8周。采用汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)于治疗前和治疗2、4、6、8周末分别评定疗效和不良反应。 结果:西酞普兰组与阿米替林组HAMD评分差异无显著性。西酞普兰组不良反应较阿米替林组少而轻。 结论:西酞普兰治疗阿尔茨海默病的抑郁疗效好,安全性高,不良反应轻微。
Objective:To compare the efficacy and security o f citalopram and amitriptyline in the treatment of depression induced by Alzheimer disease (AD). Method:Eighty patients with depression induced by AD were randomly divided into the treatment groups of citalopram or amitripty line for 8 weeks. Clinical progress was examined with HAMD and TESS. R esults:No remarkable differences in the efficacy were found between two groups,but the side effects of citalopram were fewer and milder than that of ami triptyline. Conclusion:Citalopram is an effective and safe drug in the treatment of depression associated with Alzheimer disease.
出处
《临床精神医学杂志》
2005年第2期84-85,共2页
Journal of Clinical Psychiatry
