摘要
目的:比较奎硫平与氯丙嗪对精神分裂症患者生活质量的影响。 方法:采用生活质量问卷(QOL)、阳性与阴性症状量表(PANSS)、副反应量表(TESS)、健康状况问卷(SF 36 )进行疗效、不良反应和生活质量评估,并对影响生活质量的某些因素进行多元逐步回归分析。 结果:两组PANSS评分治疗前后均有极显著差异,而两组同期相比差异则无显著性。治疗结束后,奎硫平组在生理机能、生理职能、生活活力、社会功能4个因子分及生存质量总评分均明显高于氯丙嗪组。多因素逐步回归分析显示影响患者生存质量的主要因素依次为精神症状、药物、不良反应、病程。 结论:奎硫平与氯丙嗪对精神分裂症疗效相当,生活质量影响优于氯丙嗪。
Objective:To compare the quality of life (QOL) in schizophrenic patients treated with quetiapine or chlorpromazine. Metho d:84 schizophrenic inpatients were randomly divided into two groups rece iving quetiapine and chlorpromazine respectively for 12 weeks.Positive and negat ive symptom scale (PANSS),the treatment emergent symptom scale (TESS),and short form 36 health survey questionaire (SF-36) were used to evaluate the efficacy,t he side effects and the quality of life. Results:The scores of PANSS in both groups were significantly decreased after treatment and there was no significant difference between two groups.The factor scores of physical func tioning,role-physical,vitality, social functioning and the total scores of SF- 36 were significantly higher in quetiapine group than in chlorpromazine group.A n analysis of multiple stepwise regressions showed that the main factors influen cing the patients' life quality were psychotic symptoms,drug,side effects and th e duration of disease in turn. Conclusion:Quetiapine and clopro mazine have similar efficacy in the treatment of schizophrenia,but the patients treated with quetiapine may have better life quality.
出处
《临床精神医学杂志》
2005年第2期103-105,共3页
Journal of Clinical Psychiatry
关键词
奎硫平
氯丙嗪
精神分裂症
生存质量
quetiapine
clopromazine
schizophrenia
qualits y of life
