摘要
神经干细胞和胶质瘤干细胞的研究成功,对早有定论的胶质瘤起源细胞学说发出了挑战。在胶质瘤细胞中,为数不多的干细胞是生成肿瘤的细胞已经证实,但肿瘤干细胞是否起源于神经干细胞仅仅只是推测。两者间的分子关系是研究的切入点,推测调控分子就是胶质瘤发生的分子病因。
Challenges have been proposed to the classical theory of origin cells of glioma, since the successful researches on neural stem cells and tumor stem cells. Several studies demonstrated that in different subgroups of glioma cells, a few tumor stem cells were responsible for maintaining tumor growth. Further, we can speculate tumor stem cells were derived from neural stem cells, however, molecular relationship between these two kinds of cells should be the next research focus. Regulation molecules involved in this process maybe the molecular etiology of gliomagenesis.
出处
《中华神经医学杂志》
CAS
CSCD
2005年第3期217-220,共4页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(30371457)
