摘要
目的:探讨老年人糖耐量异常(IGT)与动脉粥样硬化的关系。方法:在60岁以上的人群中筛查,按照75g葡萄糖耐量试验将研究对象分为糖尿病(DM)组、IGT组和正常糖耐量(NGT)组。抽血检查血脂及胰岛素水平,B型超声检查双侧颈总动脉内中膜厚度(IMT)。结果:IGT组的IMT值和内膜连续性比NGT组差;DM组胆固醇(CH)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及空腹胰岛素(FINS)水平均比NGT组高;以上指标IGT组与DM组差别无统计学意义。logistic回归分析表明:年龄、CH、TG、HDL、LDL水平与IGT相关。结论:与NGT组相比,IGT组存在明显的动脉粥样硬化表现,其程度与糖尿病患者接近。IGT参与动脉粥样硬化的形成。
Objective: To investigate the relationship between abnornal glucose tolerance (IGT) and atherosclerosis in the elderly. Methods: The subjects were screened among those who were over 60 years old. They were divided into diabetes mellitus (DM) group, IGT group and normal glucose tolerance (NGT) group by 75 g oral glucose tolerance test. Serum concentrations of lipid and insulin were examined. The intima-media thickness of bilateral common carotid arteries were observed by B-scanning. Results: The IMT values and intima smoothness of IGT group were worse than those of NGT group. The levels of cholesterol, triglyceride, high density lipoprotein, low density lipoprotein and fasing insulin of IGT group were lower than those of NGT group. The parameters that mentioned above had no significant difference between IGT and DM group. The logistic regression analysis showed that age, cholesterol, triglgceride high density lipoprotein and low density lipoprotein levels were associated with IGT. Conclusion: IGT subjects show more significant atherosclerotic manifestations compared with NGT ones, which is similar to DM subjects. IGT participate in the pathogenesis of atherosclerosis.
出处
《天津医药》
CAS
北大核心
2005年第4期201-203,共3页
Tianjin Medical Journal
