摘要
目的:研究胆碱对炎性疼痛的影响。方法:福尔马林实验和小鼠热板实验,观察单独给予胆碱及胆碱与阿司匹林或吗啡联合用药时,对小鼠在福尔马林模型中的舔足时间和热板实验中的疼痛潜伏期的影响。结果:胆碱(4、8、16、32、6 4mg·kg-1,i .v .)可显著抑制福尔马林所致的Ⅱ相痛反应;尾静脉给予胆碱2mg·kg-1或阿司匹林9.4mg·kg-1,对福尔马林模型的Ⅰ相和Ⅱ相痛反应均无显著的抑制作用,二者联合应用可显著抑制Ⅱ相反应;联合给予吗啡0 .16 5mg·kg-1和胆碱2mg·kg-1对福尔马林模型的Ⅱ相反应的抑制作用比单独应用吗啡0 .16 5mg·kg-1好。结论:胆碱对炎症性疼痛镇痛效果显著,胆碱和阿司匹林、吗啡有协同镇痛作用。
AIM: To investigate the antinociceptive effect of choline on inflammatory pain. METHODS: Formalin and hot-plate tests were used to study the antinociceptive effect of choline, and observe the synergetic antinociceptive effects of choline and its combination with aspirin or morpine. RESULTS: Early phase (0-5 min) response was induced by an immediate and intense increase in the spontaneous activity of afferent C fibers. Late phase (15-30 min) response was thought to be inflammatory response induced by the release of inflammatory factors after formalin administration. Choline(4, 8, 16, 32, and 64 mg·kg -1,iv)obviously shortened the paw licking time in phaseⅡ in the formalin test. The conjoint administration of choline 2 mg·kg -1 and aspirin 9.4 mg·kg -1 produced a synergistic antinociception effect compared with that administration of choline 2 mg·kg -1 or aspirin 9.4 mg·kg -1, respectively. And the phenomenon was also observed on the conjoint administration of choline 2 mg·kg -1 and morpine 0.165 mg·kg -1 compared with that administration of morpine 0.165 mg·kg -1 singly, but synergistic effect on the conjoint administration of choline 4 mg·kg -1 and aspirin 23.5 mg·kg -1 did not show obvious significance compared with that administration of choline 4 mg·kg -1 or aspirin 23.5 mg·kg -1, respectively. CONCLUTION: Choline can inhibit inflammatory pain induced by formalin. Co-administrations of choline and aspirin, or morpine have prominent synergetic antinociceptive effects.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第3期276-280,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金资助项目 (№ 3 0 3 7164 1)
北京赛德维康医药研究院新药研究基金项目资助 (№ 19990 0 1)
