摘要
目的探讨罗格列酮对自发性高血压大鼠(SHR)血管壁的保护作用。方法SHR大鼠24只,分成SHR组及罗格列酮组,罗格列酮组饮水中加入罗格列酮,用光镜和电镜的方法,评价两组大鼠主动脉内皮细胞、平滑肌细胞等形态学特点。结果SHR大鼠主动脉壁内膜层、平滑肌层均存在一些形态学方面的异常,经罗格列酮治疗后这些形态学异常得到抑制或改善。结论从形态学角度证实罗格列酮具有一定的血管保护作用。
Objective To explore the protective effects of rosiglitazone on the vascular system of spontaneous hypertensive rat (SHR). Methods 24 SHR rats were divided into observation group (rosiglitazone put into drinking water) and control group. The morphological features of endothelial cells and smooth muscle cells in aorta were evaluated by light and electro-microscope. Results Some histopathological changes appeared in the endomembrane and smooth muscle layer of aorta wall of SHR rats were inhibited or improved with rosiglitazone.Conclusions It approved that rosiglitazone could have a certain vascular protective function from the point of view of morphology.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2005年第4期416-418,共3页
Chinese Journal of Gerontology
基金
吉林省科技厅中标课题(编号:20010517)
