摘要
目的探讨肝VX2瘤模型MR扩散成像特征。方法新西兰大白兔35只,采用块种植的方法,一期预实验:皮下种植14只,肝内种植6只;二期肝内种植12只,另3只做正常对照。对包括二期肝内种植在内的15个肿瘤于种植前后行定期扩散加权成像(DWI)与MR检查。以表观扩散系数(ADC)值等为指标进行统计分析。结果(1)一期预实验,皮下种植成功率29%(4/14),肝内种植成功率33%(2/6);二期肝内种植成功率83%(10/12)。(2)VX2瘤在DWI上呈高信号,边缘清楚。正常组与VX2瘤实验组b值为100和300s/mm2时ADC值分别为(2.57±0.26)mm2/s、(1.73±0.31)mm2/s、(1.87±0.25)mm2/s与(1.57±0.23)mm2/s(F=43.26,P<0.001)。随b值增大,病灶信号降低;ADC图上病灶呈低信号;不同b值之间病灶ADC值差异有统计学意义(P<0.05);b=100s/mm2病灶与正常肝脏之间ADC值差异有统计学意义(P<0.01)。(3)VX2瘤发展迅速,易发生肺、肝、纵隔等处转移。结论DWI在反映肝VX2瘤内部水分子运动、发现与追踪病灶进展等方面有重要价值。
Objective To study the imaging characteristics of rabbit′s liver VX-2 tumor on MR diffusion-weighted imaging. Methods Of the 35 New Zealand rabbits, 14 were implanted under the skin while 6 were implanted in liver with VX-2 tumor in preparing experiment, and 12 were implanted in liver and 3 as controls in formal experiment. Before and after the implantation, MR diffusion-weighted imaging (DWI), T_1-weighted and T_2-weighted images were performed respectively and periodically in 15 tumors including 12 liver tumor implantations in formal experiment. DWI parameters including apparent diffusion coefficient (ADC) value were acquired and statistically analyzed by SPSS 10.0. Results (1)The successful rate of implantation was 29% (4/14) under the skin and 33% (2/6) in the liver in preparing experiment. And the successful rate of formal experiment was 83% (10/12).(2)DWI signal of VX-2 tumor was high and the signal became lower and lower with b value increased step by step. The signal of VX-2 tumor on ADC map was low. The ADC value of normal group was (2.57±0.26) mm 2/s (b=100 s/mm 2) and (1.73±0.31) mm 2/s (b=300 s/mm 2), and ADC value of VX-2 tumor group was (1.87±0.25) mm 2/s (b=100 s/mm 2) and (1.57±0.23) mm 2/s (b=300 s/mm 2), respectively.The F value of analysis of variance was 43.26 (P<0.001). The distinction of tumor ADC value in different b values was significant (P<0.05), and the distinction of ADC value between VX-2 tumor and normal liver was also significant (P<0.01). (3)VX-2 tumor developed quickly and metastasized early to all parts of the body, especially to the lung, the liver, the lymph nodes of mediastinum and so on. Conclusion DWI signal of VX-2 tumor has its characteristic and DWI has important value in reflecting the movement of water molecules, discovering the VX-2 tumor, and tracking its progress.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2005年第4期352-356,共5页
Chinese Journal of Radiology
基金
国家自然科学基金(30070235
30470508)
湖南省科技厅基金项目(04SK3062)
湖南省中医药管理局基金(202064
204057)
