摘要
作者从７３例根尖周炎和５７例成年人牙周炎患者临床标本中，分离获得３０种２１０株无芽胞厌氧菌，检出率为９０．０％。替硝唑对８个属２０８株厌氧菌的ＭＩＣ５０和ＭＩＣ９０明显低于甲硝唑和乙酰螺旋霉素。替硝唑体外抗革兰氏阴性无芽胞厌氧菌的作用较氯林可霉素为强，但对革兰氏阳性无芽胞厌氧菌的抗菌效果不如氯林可霉素。替硝唑和甲硝唑体内杀厌氧菌率分别为８９．６％和６２．３％，治疗根尖周炎的有效率分别为８５．４％和４４．０％，治疗成年人牙周炎的有效率分别为７６．９％和４４．４％（均Ｐ＜０．０５）。实验结果表明，替硝唑有较强的体内、外抗厌氧菌作用。
Two hundred and ten strains of anaerobic bacteria classified into 30 species were isolated from the clinical samples of 73 patients with periapical infection and 57 patients with adult periodontitis, with a positive rate of 90.0%, The MIC50 and MIC90 of tinidazole against 208 strains of anerobic bacteria from 8 genus were obviously lower than those of metronidazole and acetylspiramycin. The inhibitory effect of tinidazole on gram-positive anaerobic bacteria was weaker than that of clindamycin, but the effect of tinidazole on gram-negative bacteria was much stronger than that of clindamycin. Tinidazole and metronidazole showed their in-vivo bacteria-killing rates of to be 89.6%, and 63.3%, respectively (P<0.05). The effective rates in the treatment of periapical infection with tinidazole and metronidazle Were 85.4% and 44.0% respectively, while those in the treatment of periodontitis with the above-mentioned two drugs were 76.9% and 44.4% respectively (P< 0.05). The results showed that tinidazole had strong effect against anaerobic bacteria both in vitro and in vivo.
关键词
替硝唑
厌氧细菌
根尖牙周炎
药物疗法
Tinidazole/antag
Bacteria anaerobic/drug eff
Periapical periodontitis/drug ther
