灯盏花注射液治疗心绞痛疗效的系统评价被引量：15

Effect of Dengzhanhua Injection for Angina Pectoris: A Systematic Review

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摘要目的评价中药灯盏花注射液治疗心绞痛的疗效.方法计算机检索MEDLINE(1966～2004年)、EMBASE (1974～2004年)、Cochrane图书馆2004年第4期、中国生物医学文献光盘数据库、中文学术期刊全文数据库(1980～2004年).按纳入、排除标准纳入合格的随机对照研究并对其进行质量评价,Meta分析采用RevMan 4.2.7软件进行.结果共纳入8篇研究,包括634例患者,但这些研究的质量普遍不高.Meta 分析结果表明,西医基础治疗+灯盏花注射液(灯盏花素≥30 mg)在改善患者心绞痛症状、心电图异常方面,优于单纯西医基础治疗,其RR和95%CI分别为1.26(1.11,1.44)和1.30(1.14,1.49).灯盏花注射液(灯盏花素＜30 mg)与单纯西医基础治疗比较, 两者在心绞痛症状改善和心电图改善方面无统计学差异,其RR和95%CI分别为1.03(0.90,1.18)和1.01(0.86,1.20).此外,灯盏花还可能降低治疗后1年内心肌梗死的发生[OR 0.06, 95%CI(0.01,0.29)].结论目前仅有少量证据支持灯盏花在作为西医基础治疗的辅助药物时,在改善各类心绞痛的症状和心电图表现方面优于单纯西医基础治疗;由于纳入研究的数量少和质量不高,还不能从本系统评价得出灯盏花辅助治疗心绞痛优于单纯西医基础治疗疗效的结论. Objective To assess the effect of Dengzhanhua Injection for angina pectoris.Methods We performed an electronic search for MEDLINE (19662004), EMBASE (19742004), The Cochrane Library (Issue 4, 2004), CBM and CNKI (19802004). We included randomized controlled trials that met the inclusion and exclusion criteria and evaluated the quality of those trials and performed the meta-analysis by RevMan 4.2.7.Results Eight trials were included involving 634 patients. However, they were of poor quality. The results of meta-analysis indicated that there were statistical difference on symptoms and electrocardiogram (ECG) improvements between Dengzhanhua and control group (Breviscarpine≥30mg) with RR 1.26, 95%CI 1.11 to 1.44 and RR 1.30, 95%CI 1.14 to 1.49, respectively. However, Dengzhanhua Injection (Breviscarpine<30mg) vs. basic therapy showed no statistical difference in either symptom improvement (RR 1.03, 95%CI was 0.90 to 1.18) or ECG improvement (RR 1.01, 95%CI 0.86 to 1.20). In addition, Dengzhanhua decreased the myocardial infarction attacks in one year following up (OR 0.06, 95%CI 0.01 to 0.29). Conclusions Little evidence shows that Dengzhanhua is superior to simple basic therapy in the symptoms and ECG improvements as an auxiliary drug. However, this systematic review can not draw a conclusion about the effectiveness of Dengzhanhua Injection compared to simple basic therapy in the treatment of angina pectoris due to the poor quantity of included trials.

作者曹文斋兰德张婷唐超吴泰相刘关键

机构地区四川大学华西临床医学院四川大学华西医院循证医学与临床流行病学中心

出处《中国循证医学杂志》 CSCD 2005年第4期317-322,共6页 Chinese Journal of Evidence-based Medicine

关键词灯盏花注射液心绞痛疗效系统评价 Dengzhanhua Injection Angina pectoris Effectiveness Systematic review

分类号 R259 [医药卫生—中西医结合]

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1陈一岳,王胜涛,曾文珊,朱颖虹,傅咏梅,江涛.灯盏花素对大鼠主动脉肌环的松弛作用[J].中药新药与临床药理,1994,5(2):15-19. 被引量：30
2刘建平,Heather McIntosh,林辉.中草药治疗慢性乙型肝炎随机对照试验的系统评价[J].中国循证医学,2001,1(1):16-24. 被引量：48
3国际心脏病学会和协会及世界卫生组织临床命名标准化联合专题组.缺血性心脏病的命名及诊断标准[J].中华心血管病杂志,1981,9(2):75-75.
4AHA: Angina Pectoris [ EB/OL ]. Angina Pectoris [ serial online ] ;[cited 2004, July 24] ; Avaliable from: URL http://www, ameri-canheart, org/presenter, jhtml? identifier =4472/.
5Ford ES, Giles WH, Croft JB. Prevalence of nonfatal coronary heart disease among American adults[J]. Am Heart J, 2000; 139(3): 371-377.
6卫生部.2003年慢性疾病患病率[EB／OL].中国卫生统计年鉴2004[EB/OL].来源:URL http://61.49.18.68/statistics/digest04/s57.htm,2004.4,[引用日期2004.7.28].
7H, Shipley M, Britton A, Page M, Macfarlane P, Marmot M. Prognosis of angina with and without a diagnosis : 11 year follow up in the Whitehall Ⅱ prospective cohort study Prognosis of angina with and without a diagnosis : 11 year follow up in the Whitehall Ⅱ prospective cohort study[J]. BMJ, 2003; 10(327) : 895.
8SIGN. Drug Treatment[ EB/OL]. in: Management of Stable Angina. [ serial online ] 2001 Dec [ Cited 2004, August 2 ]. Available from: URL http ://www. sign. ac. uk/guidelines/fulltext/32/.
9Psaty BM, KoepseU TD, Wagner EH, LoGerfo JP, Inui TS. The relative risk of incident coronary heart disease associated wtih recently stopping the me of beta-blockers[J]. JAMA, 1990; 263(12) : 1 653-1 657.
10第一届全国内科学术会议心血管病组.关于冠状动脉性心脏病命名及诊断标准的建议[J].中华心血管病杂志,1981,9(1):75-76.