3Corrigan C J, KaY A B. The role of inflammatory cells in the pathogenesisof asthma and chronic obstmctive pulmonary disease. Am Rerv Respir Dis,1991,143(5): 1165 ～ 1168.
4Renkema T E, Kerstjens H A, Schouten J P, et al. The importance of serum Ig E for level and longitudinal change in airways hyperresponsiveness in COPD. Clinical & Experimental Allergy, 1998, 28(10): 1210 ～ 1218.
5Sarah A L, Ian D P, John R S, et al. The relation between peripheral blood leukocyte counts and respiratory symptoms atopy lung function and airway responsiveness in adults. Chest, 2001,119 (1):105 ～ 114.
2Fabbri LM, Losi M, Roversi P, et al. Update in chronic obstructive Pulmonary disease 2005 [ J ]. AM J Respir Crit Care Med ,2006,173 (10) : 1056 - 1065.
3Kim V, Pechulis RM, Abuel-Haija M, Small airway pathology and broncho reversibility in advanced emphysema [ J ]. COPD, 2010,7 (2) :93 - 101.
4COPD Guidelines Group of the Standards Care Committee of the BTS. BTS guidelines for the management of chronic obstructive Pulmonary disease J [ J ]. Thorax,52 suppl 5 : s28,1997, dec.
5Wan ES, Demeo DL, Hersh CP, et al. Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease ( COPD ) [ J ]. Respir Med, 2011,105 (4) : 588 - 94.
6Incorvaia C, Riario-Sforza GG, Pravettoni C,et al. Effects of replacing oxitropium with tiotropium on pulmonary function in patients with COPD : a randomized study [ J ]. Respir Med, 2007,101 ( 3 ) : 476 - 80.
