摘要
目的 研究肝脏部分切除对利多卡因在体内药代动力学的影响。方法 以肝部分切除术为试验组,以上腹部手术为对照组。硬膜外利多卡因首剂量4mg·kg-1给药后,以2mg·h·kg-1恒速滴注,于给药后不同时间取静脉血,用荧光偏振免疫法测定利多卡因血浆浓度,计算其药代动力学参数。结果 利多卡因试验组和对照组在体内的消除过程均呈一室模型,其主要药代动力学参数t1 /2分别为(147. 03±67. 05), (157. 16±33. 19)min;C120分别为(2. 90±0. 57),(2. 71±0. 38)μg·mL-1;Vd分别为(1. 60±0. 40), (1. 65±0. 26)L; AUC分别为(844. 32±295. 82), (896. 09±240. 77)μg·min·mL-1。结论 肝脏部分切除术对麻醉剂量利多卡因的体内药代动力学无明显影响。
Objective To study the effect on pharmacokinetics of lidocaine with partial hepatectomy during the operation. Methods Partial hepatectomy was chosen as the test group and abdominal operation was used as the control group. Venous blood plasma was collected before dosing and enactment time after first epidural dose of 4 mg·kg -1 and epidural infusion 2 mg·h·kg -1 of lidocaine for 2 h. The plasma concentration of lidocaine was measured by fluorescence polarization immunoassay. The pharmacokinetic parameters were calculated with pharmacokinetic non-linear program WINNOLIN. The effect on pharmacokinetics of lidocaine with partial hepatectomy was evaluated by comparing the parameters. Results The concentration-time curves of lidocaine fitted a one-compartment model for both test and control groups. The main pharmacokinetic parameters were as follow: (147.03±67.05) and (157.16±33.19) min for t 1/2 , (2.90±0.57) and (2.71±0.38) μg·mL -1 for C 120 , (1.60±0.40) and (1.65±0.26) L for V d, (844.32±295.82) and (896.09±240.77) μg·min·mL -1 for AUC, respectively. There was no significantly statistical difference between the two groups. Conclusion There was no evident effect of partial hepatectomy on pharmacokinetics of lidocaine.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2005年第2期129-131,共3页
The Chinese Journal of Clinical Pharmacology
关键词
肝脏部分切除术
利多卡因
药代动力学
荧光偏振免疫法
partial hepatectomy
lidocaine
pharmacokinetics
fluorescence polarization immunoassay
