摘要
目的研究人端粒酶逆转录酶(hHERT)在胰腺癌组织中的表达及其与临床病理的关系。方法描述胰腺癌的部位、大小、组织分级和临床分明,用SABC免疫组化方法检测hTERT的表达。结果hTERT在胰腺癌组织中表达的阳性率为81.6%,在慢性胰腺炎和正常胰腺组织中表达为0,差异有显著性(P<0.001)。hTERT的表达与肿瘤的部位、大小和组织分级无关(P>0.05),与临床分期有关(P<0.05)。结论hTERT在胰腺癌组织中有较高表达,与临床分期有关。故可以此鉴别胰腺癌和慢性胰腺炎。
Objectivev To investigate the expression of human telomerase reverse transcriptase (hTERT) and its correlation with features of clinical pathology in patients with pancreatic cancer. Methods The sites,size,histological classifications and clinical stages of the tumors were noted. Expression of hTERT was measured by SABC. Results The positive expression rate of hTERT was 81.6% in pancreatic cancer tissues, but none in chronic pancreatitis tissues and normal pancreatic tissuse (P<0.001). Expression of hTERT had to do with clinical stages(P<0.005), but not to do with site,size and histological classification(P>0.05). Conclusion There is higher expression of hTERT in pancreatic cancer tissues than in thers. Expression of hTERT is correlated with its clinical stages. Expression of hTERT can distinguish pancreatic cancer from chronic pancreatitis.
出处
《临床消化病杂志》
2005年第2期65-66,共2页
Chinese Journal of Clinical Gastroenterology
基金
广州市委基金资助(No.30000198)
中山大学附属第二医院基金资助(F002000074)
