期刊文献+

急性缺血性卒中的溶栓治疗 被引量:2

Thrombolytic Therapy for Acute Ischemic Stroke
下载PDF
导出
摘要 急性缺血性卒中的溶栓治疗是目前医学研究的热点。近年来的研究表明,溶栓治疗的时间窗应个体化。新的影像学技术有助于判断缺血半暗带和选择适合溶栓的病例。溶栓治疗的方法包括静脉溶栓、动脉溶栓和动静脉联合溶栓。影响溶栓疗效的因素包括从发病到开始溶栓治疗的时间、患者基础状况、溶栓药和联合用药、入选和治疗标准的执行情况以及是否在卒中单元内监护。 Thrombolytic therapy for acute ischemic stroke is a hotspot in current medical study. The recent studies have shown that the therapeutic time window (TTW) for thrombolytic therapy should be individualized. New imaging techniques are helpful in identifying ischemic penumbra and the selection of patients for thrombolytic therapy. The methods of thrombolytic therapy include intravenous thrombolysis, intra-arterial thrombolysis, and a combination of both. The factors that influence the thrombolysis include the time from symptom onset to beginning of thrombolysis, baseline characteristics of patients, thrombolytic agents and drug combination, the performance of the selection criteria of patients and treatment protocol, and whether patients were monitored in stroke unit.
出处 《国外医学(脑血管疾病分册)》 2005年第3期190-193,共4页 Foreign Medical Sciences Cerebrovascular Diseases
  • 相关文献

参考文献24

  • 1国家"九五"攻关课题协作组.急性脑梗死六小时以内的静脉溶栓治疗[J].中华神经科杂志,2002,35(4):210-213. 被引量:375
  • 2Adams HP Jr, Adams RJ, Brott T, et al. Guidelines for the early management of patients with ischemic stroke: A scientific statement from the Stroke Council of the American Stroke Association.Stroke, 2003, 34:1056 - 1083.
  • 3Koennecke HC, Nohr R, Leistner S, et al. Intravenous tPA for ischemic stroke team. performance over time, safety, and efficacy in a single-center, 2-year experience. Stroke. 2001 May;32 (5): 1074 -1078.
  • 4Cornu C, Boutitie F, Candelise L, et al. Streptokinase in acute ischemic stroke: an individual patient data meta-analysis: The Thrombolysis in Acute Stroke Pooling Project. Stroke, 2000, 31: 1555 - 1560.
  • 5del Zoppo GJ, Higashida RT, Furlan AJ, et al. PROACT: a phase Ⅱrandomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators.Prolyse in Acute Cerebral Thromboembolism. Stroke, 1998, 29: 4-11.
  • 6Steiner T, Bluhmki E, Kaste M, et al. The ECASS 3-hour cohort.Secondary analysis of ECASS data by time stratification. ECASS Study Group. European Cooperative Acute Stroke Study. Cerebrovasc Dis, 1998, 8:198 -203.
  • 7Patel SC, Levine SR, Tilley BC, et al. Lack of clinical significance of early ischemic changes on computed tomography in acute stroke.JAMA, 2001, 286:2830 -2838.
  • 8Alvarez-Sabin J, Molina CA, Montaner J, et al. Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator-treated patients. Stroke, 2003, 34:1235 - 1241.
  • 9Gilligan AK, Markus R, Read S, et al. Baseline blood pressure but not early computed tomography changes predicts major hemorrhage after streptokinase in acute ischemic stroke. Stroke, 2002, 33:2236 - 2242.
  • 10Selim M, Fink JN, Kumar S, et al. Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator: prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume. Stroke, 2002, 33:2047 -2052.

二级参考文献8

  • 1TheNationalInstituteofNeurologicalDisordersandStrokertPAStrokeStudyGroup.Tissueplasminogenactivatorforacuteischemicstroke[].NEngJMed.1995
  • 2MulticenterAcuteStrokeTrialItaly(MAST I)Group.Randomisedcontrolledtrialofstreptokinase,aspirinandcombinationofbothintreatmentofacuteischemicstroke[].The Lancet.1995
  • 3Hacke W,Bluhmki E,Steiner T,et al.Dichotomized efficacy end points and global end-point analysis applied to the ECASS in tention-totreat data set.Post hoc analysis of ECASS Ⅰ[].Stroke.1998
  • 4Memezawa H,Simith ML,Siesjo BK.Penumbral tissue salvaged byreperfusion following middle cerebral artery occlusion in rats[].Stroke.1992
  • 5Overgarrd K,Sereghy T,Boysell G,et al.Reduction of infarct volume by thrombolysis with rt-PA in an embolic rat stroke model[].Scandinavian Journal of Clinical and Laboratory Investigation.1993
  • 6Del Zoppo GJ,Pessin MS,Mori E,et al.Thrombolytic intervention in acute thrombolic and embolic stroke[].Seminars in Neurology.1991
  • 7The ECASS Study Group.Intravenous thrombolysis with recombinant tissue plasminogen activator for acute he mispheric stroke[].The Journal of The American Medical Association.1995
  • 8Hantson L,Deweerdt W,De keyser J,et al.The European Stroke Scale[].Stroke.1994

共引文献374

同被引文献3

  • 1C S. Rivers,J M. Wardlaw,P A. Armitage,M E. Bastin,T K. Carpenter,V Cvoro,P J. Hand,M S. Dennis.Do Acute Diffusion- and Perfusion-Weighted MRI Lesions Identify Final Infarct Volume in Ischemic Stroke?[J]. Stroke . 2006 (1)
  • 2Kim E Y,Ryoo J W,Roh H G,Lee K H,Kim S S,Song I C,Chang K-H,Na D G.Reversed discrepancy between CT and diffusion-weighted MR imaging in acute ischemic stroke. AJNR. American journal of neuroradiology . 2006
  • 3王晴川,刘广芬.抗血栓新药蕲蛇酶[J].中国新药杂志,2000,9(4):270-272. 被引量:15

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部