摘要
目的 在新生儿甲状腺功能减退症(CH)的筛查中,对脐血促甲状腺激素(TSH)增高的96例新生儿进行随访复查,以尽早确诊和治疗CH ,降低残疾儿童的发生率。方法 对2 0 0 1～2 0 0 4年出生的6 5 4 7例新生儿脐血的CH筛查中,出现TSH单项增高96例(TSH >13 2mIU/L)。对于这96例新生儿在出生后7～30d内召回复检,使用微粒子酶免分析法(MEIA)检测TSH、FT4 ;荧光偏振免疫分析法(FPIA)检测TT4。结果 复查的96例新生儿,有1例初步确诊为新生儿甲减(TSH 2 3. 9mIU/L ,TT4 2 3. 6mmol/L ,FT4 1 .5 6pmol/L) ;3例考虑为亚临床甲减(TSH升高,TT4正常) ,结论 虽然CH的发病率很低,但在检测过程中也要认真对待筛查中的异常结果,以减少CH的漏诊率,提高CH的确诊率。
Objective To call back neonates with high TSH i n umbilical cord blood who were inspected in 6 547 neonates CH screening from 200 1 to 2004,in order to diagnose and therapy as early as possible and to prevent t he children from growth and mental retardation.Methods TS H and FT4 values were measured by MEIA.TT4 value was measured by FPIA,96 neonate s with high TSH were informed to return to hospital for reexamination at their 7～30 days of age.Results Among 96 neonates,only one chil d was considered as a case of CH,3 cases subclinical hypothyroidism were conside red.Conclusion Incidence of CH is very low,but should tre at carefully abnormal results in CH screening,so could make a right diagnose as soon as possible.
出处
《现代检验医学杂志》
CAS
2005年第2期51-52,共2页
Journal of Modern Laboratory Medicine
