摘要
目的:探讨舌鳞状细胞癌(squamouscell carcinoma, SCC)中c- erbB -2 表达的临床价值。方法:回顾性分析舌SCC -76 例临床病理资料。对常规HE染色检测证实有肿瘤及瘤旁正常黏膜同时存在的原始蜡块连续切片2张,1 张c erbB 2免疫组织化学染色, 1 张备用。结果:经免疫组织化学检测, c- erbB- 2 阳性者49 例(64 .5%),瘤旁黏膜阳性者15 例( 19. 7%)。c erbB 2基因过度表达与患者生存时间差异有统计学意义,P<0 05;c- erbB -2与舌SCC的转移差异也有统计学意义,P<0 01;c- erbB- 2基因异常表达与舌SCC分期有相关性,P<0 05;c- erbB- 2基因异常表达与舌SCC分级无相关性。c- erbB- 2基因异常表达与舌SCC大小、原发灶的控制、性别、年龄无相关性;c -erbB- 2基因异常表达与局部复发无相关性。结论:在舌SCC中c- erbB- 2基因过度表达可缩短患者的生存时间,并有促进肿瘤细胞转移的可能性。
OBJECTIVE: To explore the clinical significance of c-erbB-2 in squamous cell carcinoma (SCC) of the tongue. METHODS:The data of 76 patients with SCC of the anterior tongue who were never treated before were obtained from Chinene Academy of Medical Science Cancer Hospital. Archive tissues from the 76 patients were examined for c-erbB-2 expression by immunohistochemistry. The known positive sections of breast cancer were used as control sections through all the immunohistochemical procedures. RESULTS: Of the 76 patients, positive cytoplasmic and membrance staining for c-erbB-2 was detectable in 49 (64.5%), the positive rate in paracarcinoma mucosa was 19.7%(15/76). Overexpression of c-erbB-2 was significantly correlated with short overall survival,metastasis and staging. CONCLUSIONS:The aberrant expression of c-erbB-2 is frequent in SCC of the anterior tongue. The oncoprotein of c-erbB-2 may decrease 5 years survival rate, cause metastasis easily and increase tumor stage. Thus, c-erbB-2 may be used as a prognosis marker for the patiens with SCC of the anterior tongue.
出处
《肿瘤防治杂志》
2005年第5期329-332,共4页
China Journal of Cancer Prevention and Treatment
