摘要
目的:探讨多药耐药基因1(multidrug resistance gene 1,MDR1)表达产物P- 糖蛋白(P gly coprotein,P -gp)在直肠癌组织中表达的临床意义及对预后的影响。方法: 用SABC法免疫组化染色检测62例直肠癌组织中P-gp表达情况,并与癌组织分化程度、临床分期(Duke’s分期)及预后进行相关性分析。结果:MDR1 表达产物P- gp的阳性表达与直肠癌组织病理分化程度差异有统计学意义,临床分期方面差异无统计学意义,且与预后有关。P- gp高表达者5 年生存率为43. 2%, P gp阴性表达者5 年生存率为71. 6%,两者差异有统计学意义,P=0 .034 4。结论:直肠癌组织MDR1的阳性表达具有先天耐药性,这是直肠癌术后辅助化疗效果不佳的主要原因,并影响生存率,癌组织中P -gp高表达者较阴性表达者预后差。
OBJECTIVE:To investigate the clinical significance of multidrug resistance gene expression in rectal cancer and its effects on prognosis. METHODS: Immunohistochemical stain was performed to detect P-gycoprotein(P-gp)in 62 rectal cancer biopsy samples. Relationships between P-gp expression and pathological differentiation,clinical stages were evaluated. RESULTS: No significant correlation was found between the positive rate of P-gp expression and clinical stages. However, P-gp expression showed a significant correlation with prognosis,P=0.034 4.The 5-year survival rates were 43.2% and 71.6% in positive and negative P-gp expression groups, respectively. CONCLUSIONS: Overexpression of P-gp is correlated with drug resistant of clinical chemotherapy,curative effect and survival rate in untreated rectal cancer.
出处
《肿瘤防治杂志》
CAS
2005年第5期353-354,共2页
China Journal of Cancer Prevention and Treatment
