摘要
目的 制备阿洛西林钠。方法 以氨苄西林三水酸为原料,经与侧链1-氯甲酰基- 2 -咪唑烷酮缩合得阿洛西林酸,成钠盐后,真空冷冻干燥制得阿洛西林钠。结果与结论 本制备工艺操作简便,收率高,成本低,易于工业化生产。
Objective To prepare Azlocillin sodium.Methods Ampicillin trihydrate was reacted with 1-chlorocarbonyl-2-imidazolidone to give Azlocillin acid, Azlocillin acid salted with hydroxide sodium.At last through freeze-drying,Azlocillin sodium was produced.Results and Conclusion This preparation method was simple,yield was high and the cost was low .It is suitable for industrial production.
出处
《齐鲁药事》
2005年第4期236-237,共2页
qilu pharmaceutical affairs
关键词
阿洛西林钠
制备
冷冻干爆
Azlocillin sodium
preparation
freeze-drying
