摘要
目的制备高包封率的盐酸米托蒽醌传递体,并对其制剂学进行研究。方法用薄膜法制备盐酸米托蒽醌传递体;用透射电镜、扫描探针显微镜观察形态;用激光散射仪测定粒径大小、分布及胶体溶液的Z-电位;用葡聚糖凝胶过柱法结合紫外分光光度法测定包封率;研究其体外释药特性。结果盐酸米托蒽醌传递体的形态多为圆球或近圆球形,体积平均粒径32.5nm,胶体溶液的Z-电位为-22.5mv;包封率可达100%,载药量为2.5%;体外释药无突释,48h开始在释放介质中检测出药物,312h累积释药量为总量的39.7%,符合零级释放规律。结论盐酸米托蒽醌传递体,包封率高,粒径小,缓释作用明显,有良好的应用前景。
OBJECTIVE: To prepare the mitoxantrone transforsomes with efficient encapsulation and explore sustained-release characters of transfersomes. METHODS: The mitoxantrone transforsomes were prepared by film dispersion. The particle size, particle distribution and Z-potential of colloid solution were obtained by laser scatterometer. The encapsulation efficiency was measured by sephadex gel filtration. The release of mitoxantrone transforsomes were recorded in vitro. RESULTS: The mean diameter of mitoxantrone transformes was 32.5 nm. The encapsulation efficiency of mitoxantrone was 100%. The cumulative release of the mitoxantrone transformes in PBS(7.4) was 39.7% in 312 h. The release profile in vitro was fitted well with a zero-order equation. CONCLUSION: The mitoxantrone transforsomes showed an efficient encapsulation and an obvious sustained release character.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2005年第7期522-524,共3页
Chinese Pharmaceutical Journal
关键词
盐酸米托蒽醌
传递体
包封率
缓释性
Filtration
Gelation
Laser beams
Particle size analysis
Solutions
