摘要
本实验在新西兰兔食饵性动脉粥样硬化模型上，观察了绞股蓝总皂甙预防性给药和治疗性给药对血清一氧化氮、胆固醇及过氧化脂质的影响。发现绞股蓝总皂甙（６０ｍｇ·ｄ－１）与１％胆固醇同时喂养或喂胆固醇４周后以绞股蓝总皂甙（１２０ｍｇ·ｄ－１）治疗４周均能有效抑制高脂所致的血清一氧化氮降低和过氧化脂质升高，并能保护超氧化物歧化酶活性和降低血清总胆固醇及甘油三酯的水平。
We reported the effects of gypenosides (GPS) on serum levels of nitric oxide(NO),lipid peroxidation(LPO)and superoxide dismudase(SOD)in atherosclerotic rabbit induced by high cholesterol diet.The results showed that GPS 60 mg·d-1 fed in company with 1% cholesterol for 8 weeks and GPS 120 mg·d-1 orally administrated for 4 weeks after development of aortic lesion could significantly protect the activity of NO and SOD,decrease the LPO content as well as lower the serum levels of total cholesterol and triglyceride.
出处
《中国动脉硬化杂志》
CAS
CSCD
1994年第4期149-152,共4页
Chinese Journal of Arteriosclerosis
基金
湖南省教委资助课题
