摘要
本实验在大鼠的整体及离体血管条上观察了降钙素基因相关肽（ＣＧＲＰ）对内皮素（ＥＴ）释放的影响。结果表明：ＣＧＲＰ静脉注射（５μｇ／ｋｇ）能明显降低大鼠内毒素血症时血浆ＥＴ含量，ＣＧＲＰ孵育（１０￣（－８）ｍｏｌ／Ｌ）离体的大鼠主动脉血管条能有效地抑制凝血酶（ｔｈｒｏｍｂｉｎ）引起的ＥＴ释放，但是ＣＧＲＰ静注及孵育不影响血浆ＥＴ的基础含量及离体血管条ＥＴ的基础释放。结果提示ＣＧＲＰ能抑制病理条件下ＥＴ的大量释放。
The effect of calcitonin gene-related peptide CGRP )on endothelin(ET)release was investigated in both in vivo and in vitro experiments.It was found thatintravenously injected CGRP( 5μg/kg )into rats obviously inhibited endotoxin( 15mg/kg)-induced increase (not basal)in plasma ET, incubation of isolated rat aorta withCGRP( 10￣(-8)mol/L)effectively inhibited the thrombin(4U/ml )-stimulated(not basal)ET release.These results suggested that CGRP might be an inhibitor to ET release inpathological conditions.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1994年第5期545-547,共3页
Chinese Journal of Pathophysiology
