摘要
氧自由基引起兔脑基底动脉收缩，灌注压明显增高，脑基底动脉内皮源性舒张因子释放明显减少，血管壁组织中亚硝酸盐含量及超氧化物歧化酶活性明显降低，丙二醛含量明显升高。提示氧自由基损伤脑血管作用可能与其损伤血管内皮及促进脂质过氧化产物的生成有关。
This study was to investigated the effect of exogenous oxygen free radicals(OFR)on the rabbit basilar artery. Exogenous OFR were generated by electrolysis of Krebs' solution. The perfusion pressure and malonyldialdehyde content in basilar artery were increased, meanwhile release of endothelium derived relaxing factor,nitrite content and superoxide dismutase activity decreased after OFR damage, These data indicated that OFR induced cerebral vasospasm is mainly mediated by cerebral vascular endothelial damage and lipid peroxide formation.
出处
《中国动脉硬化杂志》
CAS
CSCD
1994年第2期88-91,共4页
Chinese Journal of Arteriosclerosis
关键词
一氧化氮
超氧化物歧化酶
脑血管痉挛
氧自由基
Basilar artery
Endothelium derived relaxing factor
Lipid perxide
Superoxide dismutase
Nitric oxide
Oxygen free radicals.
