摘要
报告１２例非克汀病病区人工引产胎儿和６例地方性克汀病病区加碘盐１１年后人工引产胎儿大脑Ｍ－胆碱受体的变化。结果显示，与非病区相比．病区胎儿大脑Ｍ－胆碱受体密度（Ｂ（ｍａｘ））显著降低（Ｐ＜０．０５），而配基－受体解高常数（Ｋｄ）则明显升高（Ｐ＜０．０１）。表明病区补碘后胎儿发育过程中，大脑Ｍ－胆碱受体发育存在显著的迟滞现象，这可能是病区仍然有亚克汀病病例存在的分子基础。
To provide molecular evidences for the epidemiologic and morphologic findings on endemic cretinism,we studied the cerebral muscarinic cholinergic receptors of therapeutically aborted fetuses from an endemic cretinism region after supplement of iodized salt for eleven years with radioligand assay. The results showed that both density and affinity of the cerebral muscarinic cholinergic receptors in the fetuses (n=6) from the endemic region were significantly lower as compared with the fetuses (n=12) from the non-endemic region (P less than 0.05 and 0.01,respectively).These suggests that the development of the cerebral muscarinic cholinergic receptors in the fetuses from the endemic region after supplement of iodized salt was retarded. This may contribute to the molecular base of still many cases of cretimoid in the endemic region.
出处
《中国地方病学杂志》
CAS
CSCD
1994年第1期13-15,共3页
Chinese Jouranl of Endemiology
关键词
胎儿大脑
亚克汀病
M-胆碱受体
fetal brain cretinoid muscarinic cholinergic receptor
