期刊文献+

挥发性有机化合物对小鼠神经行为功能的影响 被引量:18

Neurotoxic Effect of Exposure of Mice to Volatile Organic Compounds
下载PDF
导出
摘要 [目的]研究室内挥发性有机化合物(VOCs)对小鼠神经行为的影响。[方法]用分析纯试剂配制成混合物,对小鼠用静式染毒柜进行亚慢性吸入染毒(3个剂量组分别是,甲醛:1.5、4.5、13 .5mg/m3 ;VOCs :2 0 .0、60 .0、180 .0mg/m3 )。观察小鼠一般情况,进行神经行为功能测试包括水迷宫、避暗、跳台、自发活动试验。[结果]染毒期间可见各染毒组小鼠活动减少,行动迟缓;雌性小鼠高剂量染毒组体重增长低于对照组,差异有显著性(P <0 .0 5 ) ;而在水迷宫、避暗、自发活动测试中,除雄性小鼠低剂量组与对照组差异无显著性外,其余雌、雄性小鼠各染毒组与对照组相比,结果差异均有显著性(P <0 .0 5 )。雄性小鼠体重增长,差异未见显著性。[结论]挥发性有机化合物可使小鼠体重减轻,活动减少,学习记忆能力下降。 Objective] To explore the combined neurotoxicity of volatile organic compounds(VOCs) exposure in mice. [Methods] The gaseous mixture of several main compounds of VOCs and formaldehyde were prepared using their pure chemical reagents.The Kunming mice were sub-acutely exposed to the prepared gaseous mixture(three groups of formaldehyde at a dose of 1.5 mg/m3,4.5 mg/m3 or 13.5 mg/m3;three groups of VOCs at a dose of 20 mg/m3,60 mg/m3 or 180 mg/m3).Neurobehavioral function tests include spatial water maze,step-down test,step-through test and pontaneous activity measurement. [Results] Significant differences were observed in all tests between exposed groups and the control group. [Conclusion] It is suggested that volatile organic compounds exposure could damage the ability of learning and memory in mice.
出处 《环境与职业医学》 CAS 北大核心 2005年第2期112-115,共4页 Journal of Environmental and Occupational Medicine
  • 相关文献

参考文献15

  • 1郭棣华,林福永,童家期.职业性接触混苯对神经行为功能的影响[J].中华劳动卫生职业病杂志,1994,12(1):42-43. 被引量:22
  • 2王秀玲,金锡鹏,王旭平,高飞.二甲苯对大鼠神经行为功能的影响[J].工业卫生与职业病,1998,24(6):336-339. 被引量:6
  • 3韩克勤 井海宁.在居室装修中挥发性有机物对室内空气的污染[J].中国环境卫生,1999,2:20-22.
  • 4张存合,王如刚,郑河新,周素梅,康秉勋,陶永娴.刷漆后房间空气中挥发性有机物种类及浓度变化规律的实验研究[J].职业与健康,2002,18(5):35-37. 被引量:2
  • 5张秀珍.南京市某小区室内空气质量卫生学调查[A]..江苏省室内环境和装修材料卫生质量检测评价方法研讨会论文集[C].,2002.3.17—19.
  • 6Hanninen H, Eskelinen L, Husman K, et al. Behavioral effects of long-term exposure to a mixture of organic solvents[J]. Scand J Work Environ Health,1976,2:240-255.
  • 7Bleeker ML,Bolla KI,Agnew J,et al. Dose-related subclinical neurobehaviioral effects of chronic exposure to low levels of organic solvents[J]. Am J Ind Med, 1991,19:715-728.
  • 8Colvin M, Myers I, Nell V, et al. A cross-sectional survey of neurobehavioral effects of chronic solvent exposure on workers in a paint manufacturing plant[J]. Environ Res, 1993,63:122-132.
  • 9Korsak Z, SwierczR, Jedrychowski R. Effects of acute combined exposure to N-butyl and M-xylene[ J]. Pol J Occup Med Environ Health, 1993,6( 1 ):35-41.
  • 10Wada H, Hosokawa T, Saito K. Single toluene exposure and change of response latency in shock avoidance performance[ J ]. Neutoxicol Teratol,1989,11(3) :265.

二级参考文献4

  • 1《中国医学百科全书》编辑委员会.环境卫生学[M].上海:上海科学技术出版社,1987.97-101.
  • 2陈自强,周霞萍,于继慧,邵民.职业性接触低浓度甲苯对机体行为功能的影响[J]卫生毒理学杂志,1989(01).
  • 3梁友信.介绍WHO推荐的神经行为核心测验组合[J]工业卫生与职业病,1987(06).
  • 4I. Dési,F. Kovács,Z. Zahumenszky,A. Balogh. Maze learning in rats exposed to xylene intoxication[J] 1967,Psychopharmacologia(3):224~230

共引文献36

同被引文献227

引证文献18

二级引证文献123

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部