摘要
本研究采用亚急性汞中毒肾损害的大鼠模型,探讨了汞中毒时血、肾和尿中碱性磷酸酶(ALP)活性的变化关系。结果表明,大鼠肾匀浆中 ALP活性明显低于对照组,尿 ALP活性则显著增加。ALP 活性降低的部位在肾近曲小管。体外实验未发现氯化汞对肾、尿ALP 具有直接抑制作用或激活作用。尿中ALP 活性的增高是汞引起的肾小管上皮细胞损伤所致。它可作为汞中毒肾损害的一个观察指标。
By means of a subacute mercury poisoning renal damage model in rat,the changes of ALP activity in blood, kidney & urine were studied. The results showed that ALP activity in renal homogenate of mercury poisoning rats was significantly lower than that of the contral,& the ALP activity in urine of mercury group was significautly increased, Histochemical study revealed that the site of ALP activity decline is in renal proxtmal convoluted tubules ( PCT) . It was not fou nd that HgCI2 had direct: activation or inhibition on ALP in kidney & urine according to the results observed in vitro. Therefore it seems that increase of ALP activity in urine results from PCT damage by mercury & may be used as an indicator of mercury poisoning renal damage.
出处
《卫生毒理学杂志》
CSCD
1989年第1期11-14,共4页
Journal of Health Toxicology
基金
国家自然科学基金
关键词
肾脏毒性
碱性磷酸酶
汞中毒
Mercury, Nephrotoxicity
ALP
Histoctemistry.
