摘要
甘糖酯是在对藻双酯钠(PSS)较系统的构效关系研究的基础上新近研制的一种低分子量、低抗凝的类肝素海洋药物。本文报道甘糖酯治疗137例急性脑梗死患者的有效率95.6％,显效率70.1％,与对照组相比有极显著性差异(P<0.001)。实验室研究发现,甘糖酯有抗凝血、降血脂、降低血粘度以及改善微循环等多方面作用。研究结果表明,甘糖酯治疗急性脑梗死有重要临床价值。
The therapeutic effect and laboratory findings in 137 case of acute cerebral infarction treated with Propylene Glycol Mannurate Sulfate (PGMS) were analysed. The positive therapeutic response to PGMS in the treated group was obtained to 95. 6% and 70. 1%,and was better than that of the controls ( P <0. 001). The laboratory findings showed that PGMS had obvious effects of anticoagulant and decreasing blood viscosity and serum lipid level. PGMS was considered to be a prospective drug in treating acute cerebral infarction.
出处
《中国海洋药物》
CAS
CSCD
1994年第4期29-33,共5页
Chinese Journal of Marine Drugs
关键词
甘糖酯
脑栓塞
海洋药物
藻酸双酯钠
Propylene glycol mannurate Sulfate (PGMS)
acute cerebral infarction (ACI)
