摘要
目的:探讨痹肿消汤对胶原诱导性关节炎(collageninducedarthritis,CIA大鼠的作用机制。)方法:用含588个基因克隆的大鼠cDNA微阵列研究CIA大鼠经痹肿消汤干预前后的滑膜基因表达谱。结果:痹肿消汤干预后大鼠差异表达基因共有29个,其中上调基因8个,下调基因21个。结论:痹肿消汤通过对多基因、多靶点的调控,可改善患者关节疼痛等功能障碍,是治疗类风湿关节炎rheumatoidarthritis,RA的有效方剂。
AIM:To investigate the mechanism of bizhongxiao decoction(BZXD) in treating rats with collagen induced arthritis(CIA). METHODS:The cDNA microarray chips containing 588 rat target genes were used to identify the gene expression profiles in synovitis of CIA rat before and after intervention of BZXD. RESULTS:After intervention of BZXD,29 differential expressed genes were identified in CIA rats,including 8 genes were up regulated and 21 were down regulated. CONCLUSION:BZXD can ameliorate the functional disorders such as joint pain through adjusting and controlling several genes and targets,and it is an effective drug for treatment of rheumatoid arthritis(RA).
出处
《中国临床康复》
CSCD
北大核心
2005年第11期42-43,共2页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金项目(30371833)
湖南省科技基金项目(02ssy4028)
湖南中医管理局基金项目(20053)资助~~
