摘要
目的:一种可能的自身抗原人类软骨糖蛋白-39(humancartilageglyco-protein-39,HCgp-39)近年来成为国外风湿病学者研究类风湿关节炎(rheumatoidarthritis,RA发病及其治疗的热点。探讨将对HCgp-39的来)源、结构和生化意义及其在RA发病中的作用。资料来源:应用计算机检索Medline1990-01/2004-01期间的HCgp-39相关文章,检索词“HCgp-39”,并限定文章语言种类为English。资料选择:选择与HCgp-39相关英文文献100篇。资料提炼:按HCgp-39的最新进展对相关文献进行提炼。资料综合:按HCgp-39的来源、结构及功能、HCgp-39与疾病的关系,尤其是HCgp-39与RA的关系进行综述。结论:HCgp-39可以作为除传统的RA疾病活动性指标之外的又一可测量指标,建立血清学检测方法对于RA的早期诊断、判断RA患者的病情、改善预后和转归也具有一定意义。可考虑用于抗原特异的免疫治疗。
OBJECTIVE:One possible autoantigen human cartilage glycoprotein 39(HC gp 39) becomes a hotspot in the researches on the morbidity and the therapy of rheumatoid arthritis(RA) by international rheumatologists in recent years.This exploration would investigate the source, structure,and biochemical significance of HC gp 39 and its effects in RA morbidity.DATA SOURCES:HC gp 39 related articles between January 1990 and January 2004 were searched by the computer on Medline with the searching word of “ HC gp 39” and the language of the article was limited in English.STUDY SELECTION:Totally 100 English literatures related with HC gp 39 were selected.DATA EXTRACTION:Related literatures were extracted according to the latest progress of HC gp 39.DATA SYNTHESIS:Summery was summed up according to the source,structure and function of HC gp 39,and the relationship between HC gp 39 and disease,especially the relationship between HC gp 39 and RA.CONCLUSION:HC gp 39 can be used as another measurable indicator except the traditional indicators for RA activity.The establishment of serological detection method has certain significance for RA early diagnosis,the judgment of the situation of RA,the improvement of prognosis and transformation.Antigen specific immunotherapy can be considered.
出处
《中国临床康复》
CSCD
北大核心
2005年第11期239-241,共3页
Chinese Journal of Clinical Rehabilitation
