摘要
目的:探讨缺氧诱导因子1α(HIF-1α)蛋白及其mRNA在妊高征和正常妊娠胎盘组织中的表达的差异。方法:应用Westernblot检测10例妊高征和10例年龄匹配的正常妊娠的胎盘组织中HIF-1α蛋白表达的水平;应用实时定量PCR,检测两种组织中HIF-1αmRNA表达的水平。结果:与正常妊娠胎盘组织相比较,妊高征胎盘组织中HIF-1α蛋白和mRNA的表达水平明显增加(P<0.05)。结论:HIF-1α在妊高征胎盘组织中表达增高,可能与妊高征的病因及病理生理有关。
AIM: To explore the differential expression of hypoxia-inducible factor-1α(HIF-1α) in placenta tissues from pregnancy induced hypertension and normal pregnancy. METHODS: The expression of HIF-1α protein and mRNA was detected by Western blot and real-time PCR, respectively. RESULTS: As compared with the expression levels of HIF-1α protein and mRNA in placenta tissues from normal pregnancy, those from pregnancy induced hypertension increased notably(P<0.05). CONCLUSION: The high expression of HIF-1α in the placenta tissues pregnancy induced may relate with pathogenesis and pathophysiological process of hypertension.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2005年第3期362-364,共3页
Chinese Journal of Cellular and Molecular Immunology
关键词
妊高征
胎盘
HIF-1Α
hypertension pregnancy
placenta
HIF-1α
