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CA125测定在宫颈腺癌诊断中的应用 被引量:3

Serum CA125 is an important diagnostic factor in cervical adenocareinoma
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摘要 目的:研究血清CA125水平变化在宫颈腺癌诊断中的应用价值。方法:对17例宫颈腺癌治疗前的血清CA125水平进行了测定,了解其与临床分期、肿瘤大小、淋巴结转移、组织学分级的关系。结果:47%(8例)患者血清CA125水平≥30U/ml,CA125均值比较显示在宫颈腺癌Ⅱb以上分期,肿瘤直径>4cm,较低分化、淋巴结转移显著增高(P<0.05,P<0.01),CA125升高占总病例数比率在以上各组亦显著增高(P<0.05,P<0.01)。结论:血清CA125以降低临界值为标准可作为宫颈腺癌诊断和预后判定的重要指标。 Objective:The purpose of this study was to determine the diagnostic significace of a pretreatment serum CA125 value in patients who were diagnosed with adenocarcinoma of the cervix.Methods:17 cases adenocarcinoma patients had pretreatment CA125 drawn.The relationship between CA125 value and FIGO stage、histologic grade、tumor diameer、lymph nodes metastases was evaluated.Results:47%(8 cases) of total cases have elevated serum CA125 value(≥30 u/ml),which was associated significantly with advanced FIGO stage、high histologic grade、tumor size and postive pelvic lymph nodes metastases(P<0.01,P<005).Conclusion:Serum CA125 could be an important diagnostic and prognostic marker for patients with cervical adenocarcinoma.
出处 《中国妇幼保健》 CAS 北大核心 2005年第9期1054-1055,共2页 Maternal and Child Health Care of China
关键词 CA125 子宫颈腺癌 诊断 CA125 adenocarcinoma diagnosis
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  • 1Smith HO, Tiffany MF Quails CR. The rising incidence of adenocarcingma relative to squamous carcinomas of the uterine cervix - a 24year population basbd study. Gynecol Oncol, 2000, 78 ( 1 ) : 97.
  • 2Ngan HYS, Cheung ANY, Lauder IJ. Prognostic signeficance of serum tumor markers in carcinoma of the cervix. Eur J Gynaecol Oncol,1996, 17 (3): 512.
  • 3Duk JM, De Bruijn HWA, Groenier KH et al. Adenocarcinoma of the uterine cervix, Cancer, 1990, 53 ( 1 ) : 93.
  • 4Alagoz T, Buller RE, Bennan M, Anderson B. what is a normal CA125 level? Gynecol Oncol, 1994, 53 (1) : 93.
  • 5Bender DP, Sorosky JI, Buller RE et al. Serum CA125 is an independent prognostic factor in cervical adenocarcinoma. Am J Gynecol, 2003,189 (1): 113.

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