摘要
目的:研究洛美沙星(lomefloxacine)在胆道手术患者的药动学。方法:施行胆道手术并行T管引流的患者静脉滴注洛美沙星200 mg,用高效液相色谱法(HPLC)测定洛美沙星在胆汁中的浓度,3P97 软件拟合药动学参数。结果:胆汁中达峰时间为(71±41)min,峰浓度为(40±59)mg·L-1,消除半衰期为(189.2±111)min。结论:胆汁洛美沙星浓度超过胆道常见病原菌的最低抑菌浓度(MIC),个体差异较大,提示该药在治疗和预防胆道感染时具有良好应用价值。
OBJECTIVE To study the pharmacokinetics and biliary concenration of lomefloxacin in patients with biliary tracts surgery.METHODS The patients having biliary tract diseases were given a surgery and T-pipe conduction, then iv. lomefloxacine 200 mg. The concentration of lomefloxacine in bile was determined with HPLC. The parameters of pharmacokinetics were calculated with a software 3P97.RESULTS T_ max = (71±41)min, C_ max = (40±59)mg·L -1, T_ 1/2 = ( 189.2±111)min.CONCLUSION The concentration of lomefloxacine in bile is higher than MIC for usual pathogenic bacteria, but its individual variation is prominent. Prevention and cure for biliary tract infection with lomefloxacine is practical.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2005年第3期211-213,共3页
Chinese Journal of Hospital Pharmacy
关键词
洛美沙星
胆道感染
药动学
lomefloxacin
biliary tract infection
pharmacokinetics
