摘要
目的探讨转化生长因子β1(TGFβ1)和铁蛋白(SF)在胃癌患者血清中的水平及其临床意义。方法应用ELISA法对35例胃癌患者的TGFβ1和SF水平进行测定,并同期检测24例健康人的血清TGFβ1和SF水平作为对照。结果胃癌患者血清TGFβ1和SF水平均明显高于正常人(P<0.01);分化较差组、浆膜浸润组及有淋巴结转移组均分别明显高于分化较好组、无浆膜浸润组及无淋巴结转移组(P<0.01～0.05);胃癌组血清TGFβ1和SF水平呈明显正相关(P<0.01)。结论血清TGFβ1和SF可能在胃癌的浸润和转移过程中发挥某种相似的作用。
Objective To determine the serum transforming growth factor-β1(TGF-β1)and ferritin(SF)levels in patients with gastric carcinoma and to analyze their clinical significance.Methods The levels of serum TGF-β1 and SF were measured by ELISA in 35 patients with gastric carcinoma and 24 normal persons as the control group.Results Serum TGF-β1 and SF levels were much higher (P<0.01)in gastric cancer patients than those in healthy control group and they were also significantly higher(P<0.01-0.05)in patients with poorly differented cancers,serosa invasion or metastatic lymph nodes,than in those with well differentiated cancers, without serosa invasion or without metastatic lymph nodes.Moreover,the level of TGF-β1 was positively correlated with that of SF in gastric carcinoma patients(P<0.01).Conclusion Serum TGF-β1 and SF may play a similar role in the invasive and metastatic processes of gastric carcinomas.
出处
《中国肿瘤临床与康复》
2005年第2期118-119,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胃肿瘤
转化生长因子-Β1
铁蛋白
Gastric neoplasms
Transforming growth factor-β1
Ferritin
