摘要
牛红细胞铜锌超氧化物歧化酶经Ｈ＿２Ｏ＿２和抗坏血酸－Ｆｅ￣（３＝）处理后与其相应抗体的反应及与抗狗、抗猪和抗人红细胞铜锌超氧化物歧化酶抗体的交叉反应均显著增强；Ｈ＿２Ｏ＿２－Ｃｕ￣（２＋）和抗坏血酸－Ｆｅ￣（３＋）处理后人血清白蛋白及人ＩｇＧ与其相应抗体的反应也显著增强。结果提示活性氧所致蛋白质抗原与其相应抗体反应的增强可能与某些自身免疫性疾病中抗原抗体复合物的形成有关．
Bovine superoxide dismtitase(SOD)treated with H_2O_2 or ascorbate-Fe
￣(3+) demonstrateda high reactivity with its antisera as well as
with the anticanine,anti porcine and antihumenSOD antisera. Following
exposure to H_2O_2-Cu￣(2+) or ascorbate -Fe￣(3+),treated-human
serum al-bumin and immunoglobulin G also reacted strongly with their
antisera. It is proposed thatthe increased reactivity of proteins
with their antibodies caused by reactive oxygen speciesmay play a
role in the formation of circulating immune complexes in autoimmune
diseases.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第2期84-86,共3页
Chinese Journal of Immunology
关键词
活性氧
蛋白质
抗原
抗体
反应
Reactive oxygen species Proteins Antigen-antibody
reaction
