摘要
目的 探讨抗纤溶药物氨甲环酸在减少前列腺切除术后出血的疗效与安全性。 方法 符合手术指征的良性前列腺增生患者177例随机分为2组,A组79例行前列腺切除,术中、术后静脉应用氨甲环酸2g/d共3d,B组98例术中、术后静脉应用六氨基己酸4g/d共3d。氰化高铁血红蛋白分光光度法测定术后3d出血量,并观察出凝血功能及副反应。 结果 A组术后3d每天出血量分别为(32. 21±20. 62)、(22. 79±16. 56)、(15. 24±13. 99)ml, 3d总出血量(70. 24±39. 86)ml,B组术后3d每天出血量分别为(65. 10±29. 40)、(38. 89±20. 14)、(24. 00±15. 64)ml, 3d总出血量(127. 99±58. 65)ml, 2组术后3d每天出血量及总出血量差异均有统计学意义(P<0. 001)。2组凝血酶原时间、部分凝血活酶时间均无明显改变,无严重副反应发生。 结论 静脉应用氨甲环酸抗纤溶治疗对前列腺手术后止血安全有效。
ObjectiveTo study the efficacy and safety of tranexamic acid in antifibrinolytic treatment to reduce bleeding after prostatectomy.MethodsA series of 177 patients with benign prostatic hyperplasia were randomly assigned to receive tranexamic acid at 2 g/d during and after prostatectomy for 3 days (group A, n =79),and epsilion aminocaproic acid (EACA) at 4 g/d during and after prostatectomy for 3 days (group B, n =98). The bleeding volume,coagulation function and adverse effects were observed.ResultsThe bleeding volume of group A on 3 post-operative days were (32.21±20.62)ml,(22.79± 16.56 )ml and (15.24±13.99)ml,respectively;and the total bleeding volume of 3 days was (70.24± 39.86 )ml.These values were less than those of group B,which was (65.10±29.40)ml,(38.89±20.14)ml, (24.00±15.64) ml,and (127.99±58.65) ml,respectively.The differences were statistically significant ( P <0.001).Pre- and post-operatively, the coagulation system had no significant change, and no major adverse effects occurred in both groups.ConclusionsTranexamic acid is more effective than EACA in reducing bleeding after prostatectomy, and both of them are safe to the patients.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2005年第5期305-307,共3页
Chinese Journal of Urology
