摘要
目的:研究辛芩片对豚鼠鼻超敏反应的影响。方法:采用2,4二异氰酸甲苯酯(TDI)为致敏原,对豚鼠行鼻内给药建立鼻超敏反应实验模型,观察辛芩片对豚鼠鼻超敏反应模型鼻部症状、病理组织学及对鼻黏膜中组胺含量、一氧化氮合酶(NOS)活性的影响。结果:辛芩片能明显减轻鼻部症状及鼻黏膜病理改变,可显著降低鼻超敏反应模型豚鼠鼻黏膜中组胺的含量、抑制一氧化氮合酶的活性。结论:辛芩片对鼻超敏反应有显著疗效,可有效防治变应性鼻炎的发生。
Objective: To study the influence of Xinqin tablets on guinea-pig nasal hypersensitivity. Method: 2,4-Toluene Diisocyanate (TDI) was selected as antigen and used in nose to establish guinea-pig allergic rhinitis. The effects of Xinqin tablets on symptoms of nasal hypersensitivity in guinea-pigs, histamine content of nasal mucosa and activity of nitric oxide synthase(NOS)were examined. Result: Xinqin tablets could significantly relieve the pathological symptoms of nasal hypersensitivity in guinea-pig, reduce histamine content of nasal mucosa and inhibit the activity of nitric oxide synthase. Conclusion: Xinqin tablets have significant effect on nasal hypersensitivity, and prevent the occurrence of allergic rhinitis.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第10期785-788,共4页
China Journal of Chinese Materia Medica
