摘要
目的 观察小剂量阿罗洛尔治疗原发性高血压的疗效,并与美托洛尔比较。方法 采用随机对照方法,将原发性高血压患者91例,随机分为阿罗洛尔治疗组4 4例和美托洛尔治疗组4 7例,其中阿罗洛尔组用阿罗洛尔5mg ,12服,每日二次,治疗4周前后自身血压比较,分析两种药物降压效果,并进行两组间疗效比较。观察组部分病例进行动态血压监测,比较分析疗效。结果 阿罗洛尔治疗组平均坐位血压由治疗前的2 1.6 8/ 13.85±1.6 1/ 0 .79kPa下降到18.5 6 / 11.8±1.5 2 / 0 .5 9kPa ,(P <0 .0 1)。心率从80 .3±8.7次/min下降到71.3±6 .1次/min(P <0 .0 1)。两组间治疗有效率比较无显著差异P >0 .0 5 ,动态血压监测提示两组均可平稳控制2 4h血压,保持昼夜节律。结论 小剂量阿罗洛尔能降低轻、中度原发性高血压患者的血压,疗效显著,且较少发生副作用。
Objective To observe the effects of Arotinolo l on patients with essential hypertension.Methods 91 patients with mild to moderate essential hyper tension were divided randomly into Arotinolol group( group A,n=47) and Metop rolol group( group M,n=53),and treated for 4 weeks.The blood pressure before and after the treatment between two groups were compared and the ambulatory blo od pressure monitoring(ABPM) were examined in some cases. Results The mean blood pressure of group A was lowered fr om 21.68/13.85±1.61/0.75 kPa to 18.56/11.8±1.52/0.59 kPa.The heart rate decrea sed from 80.3±8.7 min to 71.3±6.1 min (P<0.01).Between two groups before and after the treatment,and no significant difference between the percentage of responders for two groups (P>0.05).Ambulatory blood pressure monitoring exam showed that the two groups could both control 24 h blood pressure, and also kee p the rhythm day and night.Conclusion Arotinolol can lower the blood pressure of mil d to moderate essential hypertension,and a steady blood pressure can be maintain ed by it throughout 24 h without fluctuation.
出处
《同济大学学报（医学版）》
CAS
2005年第2期48-52,共5页
Journal of Tongji University(Medical Science)
关键词
阿罗洛尔
原发性高血压
动态血压监测
Arotinolol
essential hypertension
ambulator y blood pressure monitoring
