摘要
肝细胞性肝癌(hepatocellularcarcino ma,HCC)是一种常见的恶性肿瘤。除少数可以手术治疗的早期肝癌外,对进展期的肝癌仍然没有合适的治疗方法。然而近几年出现了几种新的治疗手段,可能将肝癌的治疗带入一个新阶段。综述了HCC的不同治疗方法的优劣热。如何按照肿瘤分期选择最佳的治疗方法是提高疗效的关键。早期肝癌应手术切除,局限性伴有肝硬化的肝癌适合于肝移值,不宜手术切除的肝癌可选择经皮穿刺乙醇泊主射(PEI)、经肝动脉栓塞(TAE)、射频消融(RF)等治疗方法,全身化疗适用于有门脉系统侵犯的或远处转移的患者。联合化疗方案较单药好,如FEP方案。一些新的化疗药物及靶向治疗也显示出了一定的希望,最终的结果还有待临床试验进行评价。
Hepatocellular carcinoma (HCC) is one of t he commonest malignancies worldwide. Except for potentially curative surgery for e arlier stage HCC, there is still no adequate therapy for advanced HCC. However, there are several new therapeutics that might help to get into novel period in H CC recently. The article elaborates on the different remedies for HCC and their advantages and disadvantages. How to according to the stage to choose the best a dequate therapy is the key of improvement efficiency. Resectional therapy is usu ally employed for early stage HCC. Local HCC with cirrhosis should be treated wi th liver transplantion. PEI, TAE, RE are adequate therapies for unresection HCC. System chemotherapy should be used in the patients with distant metastasis or p ortal vein invasion. Combination therapies are better than sigle agent, such as FEP. Some new chemotherapy agents and targeted therapeutics have shown some prom ising results that are being further evaluated in clinical trials.[
出处
《肿瘤防治杂志》
2005年第6期471-474,共4页
China Journal of Cancer Prevention and Treatment
关键词
肝肿瘤/治疗
综述文献
liver neoplasms/therapy
review literature
