摘要
目的 介绍CT引导下组织间置入125I粒子治疗肺癌的技术方法并评价其临床价值。方法 31例肺癌患者均在CT引导下进行肿瘤内125I粒子置入术。首先根据肿瘤的大小利用放射性粒子治疗计划系统计算出治疗肿瘤所需要125I粒子的最佳数量,然后经CT引导下经皮穿刺将125I粒子均匀置入到肿瘤内进行组织间放疗,术后1、2、6个月内分别进行CT检查对患者随访,根据肿瘤大小变化将疗效分为4级:Ⅰ级:明显缓解(肿瘤缩小50%以上);Ⅱ级:缓解(肿瘤缩小, 25% ~50% );Ⅲ级:轻度缓解(肿瘤缩小1% ~25% );Ⅳ级:无效(肿瘤无变化或增大,临床症状亦无缓解)。结果1个月:Ⅰ级9例,Ⅱ级6例,Ⅲ级13例,Ⅳ级3例(包括1例失访者), 1个月有效率为90. 32%; 2个月:Ⅰ级17例,Ⅱ级8例,Ⅲ级3例,Ⅳ级3例(包括2例失访者), 2个月有效率为90 .32%; 6个月:Ⅰ级23例,Ⅱ级3例,Ⅲ级2例,Ⅳ级3例(包括2例失访者), 6个月有效率为90. 32%。结论 CT导向下组织间置入125I粒子是1种治疗肺癌安全、可靠、疗效显著的治疗方法。
Objective To introduce the procedures and evaluate the clinic value of CT-guided interstitial 125I seeds implantation in treating lung cancer. Methods Thirty-one cases patients with lung cancer underwent CT-guided interstitial 125I seeds implantation. All patients were scanned on multi-spiral CT (Philips, MX 8000) with optical navigating system (pinpoint), and treatment plan system, needle, and 125I seeds (Chinese Academy of Science) were used. First of all, according to the size of tumor, TPS calculated the optimal quantity of seeds. Then, under the guidance of CT, 125I seeds were percutaneously implanted into the tumors for interstitial radiotherapy. CT follow-up examinations were performed 1, 2, and 6 months after the therapy, respectively. According to the size of tumor, curative effects were graded as 4 grades: grade Ⅰ: obvious relief (OR) (the size of tumor reduced up to 50%), grade Ⅱ: relief (PR) (the size of tumor reduced by 25%-50%), grade Ⅲ: slight relief (SD) (the size of tumor reduced by 1%-25%), and grade Ⅳ: no effect (PD) (the size of tumor did not reduce or increase, and clinic symptoms showed no relief). Results At 1 month, 9 cases were classified as grade Ⅰ, 6 as grade Ⅱ, 13 as grade Ⅲ, and 3 as grade Ⅳ, respectively. At 2 months, 17 cases were grade Ⅰ, 8 grade Ⅱ, 3 grade Ⅲ, and 3 grade Ⅳ, respectively. At 6 months, 23 cases were grade Ⅰ, 3 grade Ⅱ, 2 grade Ⅲ, and 3 grade Ⅳ, respectively. Conclusion CT-guided interstitial 125I seeds implanted was a safe, reliable, and effective curative method for lung cancer.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2005年第5期490-492,共3页
Chinese Journal of Radiology
