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人工寒潮时不同血压水平大鼠脑卒中发病的实验研究 被引量:15

The effect of artificial cold on incidence of stroke in rats with different blood pressure level
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摘要 目的探讨人工寒潮时不同血压水平对脑卒中发病的影响。方法360只大鼠分为寒潮和非寒潮2大组,再按血压水平各分为正常血压组、160~199mmHg、200~219mmHg和≥220mmHg等4个亚组,观察大鼠的脑卒中情况。结果脑卒中发生率在血压<220mmHg与≥220mmHg的大鼠、寒潮组与非寒潮组之间均有显著性差异。脑动脉病变严重的卒中率更高。Logistic回归发现只有寒潮前高血压是脑卒中发生的唯一独立危险因素。结论高血压、寒潮与脑卒中发病密切相关,脑动脉病变是患病基础,高血压是脑卒中的独立危险因素,而寒潮是重要的启动因子。 Objective To investigate the effect of artificial cold on incidence of stroke in rats with different blood pressure level. Methods 360 male Sprague-Dawley rats were used throughout the study. 180 rats were treated with artificial cold, 180 rats treated without cold. Each group was divided into 4 blood pressure level: normal blood pressure, 160~199 mmHg, 200~219 mmHg and ≥220 mmHg. The incidence of stroke was analyzed. Results There were significant differences in incidence of stroke between rats treated with and without cold, as between rats with blood pressure more and less than 220 mmHg. Incidence of stroke was higher in rats with serious cerebrovascular pathological changes. Logistic regression showed that hypertension was the unique independent risk factor for stroke. Conclusions High blood pressure and cold were associated with higher incidence of stroke. High blood pressure is an independent risk factor for stroke, and cold is an important facilitating factor. The cerebrovascular pathological changes are more obvious in stroke rats.
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2005年第3期180-184,i013,共6页 Chinese Journal of Nervous and Mental Diseases
基金 国家自然科学基金资助(编号:30471917)
关键词 人工寒潮 高血压 易卒中型肾血管性高血压大鼠 脑卒中 Artificial cold Hypertension Stroke-prone renovascular hypertensive rat Stroke
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参考文献10

  • 1Field TS, Hill MD. Weather, Chinook, and stroke occurrence. Stroke,2002,33(7): 1751.
  • 2Feigin VL, Nikitin YP, Bots ML, et al. A population-based study of the associations of stroke occurrence with weather parameters in Siberia, Russia(1982 ~ 1992). Eur J Neurol, 2000,7(2): 171.
  • 3Lejeune JP, Vinchon M, Amouyel P, et al. Association of occurrence of aneurysmal bleeding with meteorologic variations in the north of France.Stroke, 1994,25(2) :338.
  • 4Zeng J, Zhang Y, Mo J, et al. Two-kidney, two clip renovascular hypertensive rats can be used as stroke-prone rats. Stroke, 1998,29(8): 1708.
  • 5黄如训,肖小华,李玲,罗森波,高庆春,黄海威,殷梅,高桂明,杨亚正.气象因素促发卒中的实验研究[J].中华老年医学杂志,2001,20(5):366-368. 被引量:33
  • 6解龙昌,黄如训,李常新,廖松洁,刘冰,陈立云,温红梅,王新,叶钦勇,施晓耕,林健雯.人工寒潮促发脑卒中的实验研究[J].中国神经精神疾病杂志,2004,30(3):198-201. 被引量:40
  • 7黄如训,曾进胜,苏镇培,陈颖贤,潘勇辉,黎锦如.易卒中型肾血管性高血压大鼠模型[J].中国神经精神疾病杂志,1991,17(5):257-260. 被引量:106
  • 8黄如训,曾进胜,苏镇培,陈颖贤,潘勇辉,黎锦如.肾血管性高血压大鼠自发脑卒中[J].中国神经精神疾病杂志,1992,18(3):140-142. 被引量:19
  • 9Klungel OH, Stricker BH, Paes AH, et al. Excess stroke among hypertensive men and women attributable to undertreatment of hypertension.Stroke, 1999, 30(7): 1312.
  • 10黄如训.卒中前状态和启动因子[J].中国神经精神疾病杂志,2005,31(1):73-75. 被引量:21

二级参考文献16

  • 1曾进胜,黄如训.易卒中肾血管性高血压大鼠模型及其应用[J].中山医科大学学报,1996,17(4):241-244. 被引量:27
  • 2Feigin VL,Nikitin YP,Bots ML,et al.A population-based study of the associations of stroke occurrence with weather parameters in Siberia,Russia(1982 ~ 92).Eur J Neurol,2000,7(2):171.
  • 3Lejeune JP,Vinchon .M,Amouyel P,et al.Association of occurrence of aneurysmal bleeding with meteorologic variations in the north of France.Stroke,1994,2.5(2):338.
  • 4Zeng J,Zhang Y,Mo J,et al.Two-kidney,two clip renovascular hypertensive rats can be used as stroke-prone rats.Stroke,1998,29(8):1708.
  • 5Hong YC,Rha JH,Lee JT,et al.Ischemic stroke associated with decrease in temperature.Epidemiology,2003,14(4):473.
  • 6Feigin VL,Nikitin Iup,Vibers DO,et al.Epidemiology of stroke in Siberia.Zh Nevrol Psikhiatr Im S S Korsakova,2001,101(1):52.
  • 7Lanska DJ,Hoffmann RG.Seasonal variation in stroke mortality rates.Neurology,1999,52(5):984.
  • 8Field TS,Hill MD.Weather,Chinook,and stroke occurrence.Stroke,2002,33(7):1751.
  • 9吴彦元,葛其方.北京地区冠心病,脑卒中发病与气象关系的探讨[J].中华流行病学杂志,1990,11(2):88-91. 被引量:32
  • 10程彦杰,黄铁银,杨宝琴.五运六气产生与适合的疆域问题[J].北京中医药大学学报,2000,23(1):12-13. 被引量:18

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