摘要
目的:以神经内分泌免疫调节网络学说为指导,结合中医学对糖尿病的认识,对糖尿病的病因和发病机制进行综述。资料来源:应用计算机检索Medline1980-01/2005-01的文章,检索词“Diabetesmellitus,pathogenesis,neuroendocrineimmunomodulation,tra-ditionalChinesemedicine”,并限定语言种类为English。同时计算机及手工检索万方数据资源系统与中国期刊全文数据库1990-01/2005-01的文章,限定文章语言种类为中文,检索词“糖尿病,发病机制,神经内分泌免疫调节,中医药”。手工检索1980年以后出版的有关糖尿病专著中有关中医药治疗糖尿病与神经内分泌免疫关系的章节。资料选择:对资料进行初审,选取有关糖尿病疾病与神经内分泌免疫调节网络关系的文章。纳入标准为①随机对照临床试验,采用单盲、双盲或非盲法。②非随机对照试验。③前后对照试验研究。排除标准:排除重复性研究。资料提炼:共收集到33篇关于糖尿病发病机制相关文章,其中21篇符合纳入标准。排除的12篇均为重复性文章。之间关系的文章进行分析,探讨三者之间的内在联系。资料综合:对21篇有关糖尿病病因与神经内分泌免疫调节及中医学。结论:糖尿病的发病系由遗传因素与环境因素相互作用,通过神经内分泌免疫调节网络中胰岛素及其反调激素以及下丘脑-垂体-
OBJECTIVE:To review the pathogenesis of diabetes under the guidance of the theories of neuroendocrine immunomodulation(NIM) network combined with the understanding of diabetes in traditional Chinese medicine. DATA SOURCES:Computer was used to search for the articles published from January 1980 to January 2005,with key words of “diabetes mellitus,pathogenesis,neuroendocrine immunomodulation,and traditional Chinese medicine ' and the language of the papers was limited to “English'.Also,computer and manual search for the articles in NLW and CNKI data banks from January 1990 to January 2005 were made with the language of the papers being limited to “Chinese' and key words of “diabetes,pathogenesis,neuroendocrine immunomodulation,traditional Chinese medicine'. Manual search was made for book chapters on the treatment of diabetes by traditional Chinese medicine and papers on the relation of diabetes with neuroendocrine immunoregulation network published after 1980. STUDY SELECTION:A rough check was made firstly to the materials to choose the articles on diabetes and the relationship with neuroendocrine immunoregulation network.Inclusion criteria:①randomized clinical trial(RCT),single-,double-or non-blinded methods were used;②non-randomized controlled trial;③anterior-posterior controlled trial. Exclusion criteria:repeated studies were excluded. DATA EXTRACTION:Thirty-three articles on pathogenesis of diabetes were obtained and among them 21 were consistent with the above criteria and 12 were excluded for repetition of the same studies. DATA SYNTHESIS:Twenty-one articles on the relation of the pathogenesis of diabetes with neuroendocrine immunoregulation and with the traditional Chinese medicine were analyzed to investigate the internal relations of the three. CONCLUSION:Diabetes mellitus is induced by the interaction between genetic and environmental factors,and the imbalance among insulin,counterregulatory hormones and other factors such as hypothalamic pituitary-adrenal(HPA) axis,thymus gland in neuroendocrine immunomodulation(NIM) network.The authors propose that the NIM network theory might be as a bridge to link modern medicine and the traditional Chinese medicine that is helpful to understand the pathogenesis of diabetes mellitus.
出处
《中国临床康复》
CSCD
北大核心
2005年第15期227-230,共4页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金资助项目(30472186)~~
